Unique MicroRNA expression of Head and Neck Cancer; Analysis and Potential for Treatment Targets

• Project/Area Number: 21791644
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: INAGAKI Koji Keio University, 医学部 (70348738)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 頭頸部外科学 / 頭頸部癌 / 癌 / 遺伝子

Research Abstract

We found specific regulations of miRNAs in head and neck cancers. To confirm these findings, we examined the effect of these miRNAs on cell growth and viability using head and neck cancer cell lines. This study showed that inhibition of miR-196a suppressed the cell growth.

Research Products

• [Presentation] 頭頸部腫瘍とmiRNA(5)-新たな治療標的としてのmiRNAs- (2009)
  • Author(s): 稲垣康治、齋藤康一郎、宇野光祐、小川郁、座間猛
  • Organizer: 日本気管食道科学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] 頭頸部腫瘍とmiRNA(5)-新たな治療標的としてのmiRNAs- (2009)
  • Author(s): 稲垣康治
  • Organizer: 日本気管食道科学会
  • Place of Presentation: 横浜ベイシェラトン(横浜市)
  • Year and Date: 2009-11-05
• [Presentation] 頭頸部癌におけるマイクロRNA (2009)
  • Author(s): 宇野光祐、齋藤康一郎、稲垣康治、平沢晃、大久保啓介、座間猛
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 喉頭癌におけるマイクロRNA-3新たな治喉頭癌におけるマイクロRNA-3新たな治療標的としてのマイクロRNA (2009)
  • Author(s): 稲垣康治、齋藤康一郎、長西秀樹、大久保啓介、赤羽智子、平沢晃、座間猛
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-12
• [Presentation] 喉頭癌におけるマイクロRNA-3.新たな治療標的としてのマイクロRNA (2009)
  • Author(s): 稲垣康治
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: ロイトン札幌(札幌市)
  • Year and Date: 2009-06-12
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 頭頸部腫瘍増殖抑制剤 (2010)
  • Inventor(s): 座間猛、齋藤康一郎、平沢晃、稲垣康治
  • Industrial Property Rights Holder: 慶應義塾大学
  • Filing Date: 2010-04-16
• [Patent(Industrial Property Rights)] 頭頸部腫瘍増殖抑制剤 (2010)
  • Inventor(s): 座間猛、稲垣康治, 他2名
  • Industrial Property Rights Holder: 慶應義塾大学
  • Filing Date: 2010-04-16
• [Patent(Industrial Property Rights)] 頭頸部腫瘍増殖抑制剤 (2009)
  • Inventor(s): 座間猛、齋藤康一郎、平沢晃、稲垣康治
  • Industrial Property Rights Holder: 慶應義塾大学
  • Industrial Property Number: 2009-270157
  • Filing Date: 2009-11-27
• [Patent(Industrial Property Rights)] 頭頸部腫瘍増殖抑制剤 (2009)
  • Inventor(s): 座間猛、稲垣康治, 他2名
  • Industrial Property Rights Holder: 慶應義塾大学
  • Industrial Property Number: 2009-270157
  • Filing Date: 2009-11-27