| Project/Area Number |
21791658
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
SHIBATA Minori University of Occupational and Environmental Health, Japan, 医学部, 助教 (90512187)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | 鼻科学 / 温度センサー / TRPチャネル / ヒト / 鼻 |
|---|
| Research Abstract |
The relationship between the nose and thermo-sensitive TRP channels using fluorescent immunohistochemistry and confocal laser scan microscope was examined. Specific distribution of TRPV1 and TRPM8 was found in the human inferior turbinate. Moreover, co-localization of the inflammatory mediators SP, CGRP, a nerve marker PGP9.5 with TRPV1 and M8 were examined.
These findings suggest the possibility of a new mechanism to regulate the nasal conditions without autonomic nerve reflex.
|
