Study of epigentic mechanism underlying age-related hearing loss
Project/Area Number |
21791659
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | 独立行政法人国立病院機構東京医療センター(臨床研究センター) (2011) 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2009-2010) |
Principal Investigator |
MUTAI Hideki 独立行政法人国立病院機構東京医療センター(臨床研究センター), 聴覚平衡覚研究部, 研究員 (60415891)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 耳科学 / 神経科学 / 老化 / ゲノム / エピジェネティクス |
Research Abstract |
Auditory function is important for social communication. This study revealed evidence of epigenetic regulatory mechanism in rodent and primate auditory sensory epithelia. In DBA/2J, a mouse model of progressive/age-related hearing loss, several genes were found to change the genomic methylation levels as well as transcritpion levels in the auditory epithelium during progress of hearing loss. Treatment of the animals with drugs to modfy epigenetic mechanism successfully attenuated the progress of hearing loss.
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Report
(4 results)
Research Products
(33 results)