Cure development of anticancer agent sensitivity and the cancer stem cell in head and neck cancer

• Project/Area Number: 21791660
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: 愛知県がんセンター (2011); Nagoya University (2009-2010)
• Principal Investigator: SUZUKI Hidenori 愛知県がんセンター, 研究所・腫瘍病理学部, 研究員 (70470169)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頭頸部外科学 / FDG-PET / FDG-PET/CT / 頭頸部癌 / 抗癌剤感受性 / 癌幹細胞 / 治療抵抗性 / 抗がん剤感受性 / 頭頚部癌 / Sox2 / 抗癌剤感受性試験

Research Abstract

In oral squmous cell carcinoma, SUVmax was related with tumor thickness and depth of invasion. Tumors with SUVmax ≧12 showed shorter 3-year overall survival, greater tumor thickness and depth of invasion, and higher average Bcl-2 intensity. SUVmax is non-invasive and useful parameter for predicting patients’ prognosis.

Research Products

• [Journal Article] Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas (2009)
  • Author(s): Suzuki H, Fukuyama R, Hasegawa Y, Tamaki T, Nishio M, Nakashima T, Tatematsu M.
  • Journal Title: Oral Oncol. Volume: 45(10)
  • Peer Reviewed
• [Journal Article] Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas (2009)
  • Author(s): Hidenori Suzuki
  • Journal Title: Oral Oncology 45 Pages: 891-897
  • Peer Reviewed
• [Journal Article] Expression of osteopontin and CDX2: indications of phenotypes and prognosis in advanced gastric cancer
  • Author(s): Zhang X, Tsukamoto T, Mizoshita T, Ban H, Suzuki H, ToyodaT, Tatematsu M.
  • Journal Title: Oncol Rep. Volume: 21(3)
  • Peer Reviewed
• [Presentation] 喉頭癌と下咽頭癌における切除病理所見と術前情報の検討 (2011)
  • Author(s): 鈴木秀典
  • Organizer: 第63回日本気管食道科学学会
  • Place of Presentation: 名古屋東急ホテル(名古屋)
  • Year and Date: 2011-11-11
• [Presentation] FDG UPTAKE PREDICTS IN PATIENTS WITH HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA (2011)
  • Author(s): 鈴木秀典
  • Organizer: 1^<st> Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2011-07-05
• [Presentation] FDG UPTAKE PREDICTS SURVIVAL IN PATIENTS WITH HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA (2011)
  • Author(s): 鈴木秀典
  • Organizer: 1^<st> Congress of the Confederation of European Otorhinolaryngology and Head and Neck Surgery
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2011-07-05
• [Presentation] 下咽頭癌におけるFDG-PETによる予後予測についての検討 (2011)
  • Author(s): 鈴木秀典
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: ウィンク愛知(名古屋)
  • Year and Date: 2011-06-09
• [Presentation] 下咽頭癌におけるFDG-PETによる予後予測についての検討 (2011)
  • Author(s): 鈴木秀典
  • Organizer: 第35回日本頭頚部癌学会
  • Place of Presentation: ウインク愛知(名古屋)
  • Year and Date: 2011-06-09
• [Presentation] 下咽頭癌におけるFDG集積 (2011)
  • Author(s): 鈴木秀典
  • Organizer: 第28回東海頭頸部腫瘍研究会
  • Place of Presentation: ウィンク愛知(名古屋)
  • Year and Date: 2011-03-05
• [Presentation] 下咽頭癌におけるFDG集積 (2011)
  • Author(s): 鈴木秀典
  • Organizer: 第28回東海頭頸部腫瘍研究会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2011-03-05
• [Presentation] 前腸発生に深く関与する転写因子Sox2の頭頸部癌における意義 (2009)
  • Author(s): 鈴木秀典
  • Organizer: 第61回日本気管食道科学総会
  • Place of Presentation: 横浜ベイシェラトン(神奈川)
  • Year and Date: 2009-11-06
• [Presentation] 前腸発生に深く関与する転写因子Sox2の頭頸部癌における意義 (2009)
  • Author(s): 鈴木秀典
  • Organizer: 第61回 日本気管食道科学会総会
  • Place of Presentation: 横浜ベイシェラトン(神奈川)
  • Year and Date: 2009-11-06