| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In the present study, we have attempted to clarify the mechanism of corneal epithelial stem cell niche. The result showed that N-cadherin was specifically expressed in the intracellular region of the corneal epithelial stem cells and the expression was rapidly lost during the differentiation of corneal epithelial cells. In certain culture condition, N-cadherin expression could be maintained for short period. Interestingly also in that condition, the expression of Keratin 12 ; differentiation marker for corneal epithelium, was increased. These results indicated that N-cadherin has important roles in not only the maintenance of" stemness" but also the corneal epithelial differentiation.
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