N-cadherin-Mediating System for Corneal Epithelial Stem Cell Niche
| Project/Area Number |
21791665
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University (2010-2011)
Tohoku University (2009) |
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Principal Investigator |
HAYASHI Ryuhei 大阪大学, 医学系・研究科, 助教 (70535278)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 角膜上皮幹細胞 / 幹細胞ニッチ / N-cadherin / 組織幹細胞 / 再生医学 / 幹細胞・前駆細胞 / 角膜上皮 / メラノサイト / 細胞間接着 / コロニーアッセイ |
|---|
| Research Abstract |
In the present study, we have attempted to clarify the mechanism of corneal epithelial stem cell niche. The result showed that N-cadherin was specifically expressed in the intracellular region of the corneal epithelial stem cells and the expression was rapidly lost during the differentiation of corneal epithelial cells. In certain culture condition, N-cadherin expression could be maintained for short period. Interestingly also in that condition, the expression of Keratin 12 ; differentiation marker for corneal epithelium, was increased. These results indicated that N-cadherin has important roles in not only the maintenance of" stemness" but also the corneal epithelial differentiation.
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Report
(4 results)
Research Products
(52 results)
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[Presentation] 角膜上皮再生医療2011
Author(s)
林竜平、西田幸二
Organizer
第31日本炎症・再生医学会シンポジスト
Place of Presentation
東京
Year and Date
2011-08-05
Related Report
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[Presentation] 角膜上皮幹細胞ニッチ2011
Author(s)
林竜平、西田幸二
Organizer
第1回わかもと先進眼科医療研究会東京
Place of Presentation
ロイヤルホテル(東京)(招待講演)
Year and Date
2011-07-29
Related Report
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[Presentation] 角膜上皮再生医療2010
Author(s)
林竜平、西田幸二
Organizer
日本炎症再生医学会
Place of Presentation
京王プラザホテル(招待講演)
Year and Date
2010-08-05
Related Report
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