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The functional analysis of the vitreous derived cells for the new therapeutic strategy of the intraocular proliferative diseases.

Research Project

Project/Area Number 21791668
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionYamagata University

Principal Investigator

NISHITSUKA Koichi  Yamagata University, 医学部, 助教 (60422169)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords硝子体細胞 / 眼内増殖性疾患 / ヒアルロナン / 糖尿病網膜症 / 増殖硝子体網膜症 / 眼細胞生物学 / 増殖糖尿病網膜症 / 増殖性硝子体網膜 / 4-メチルンベリフェロン / アポトーシス / TNF-alpha / 共培養 / サイトカイン / 血管内皮細胞 / 細胞株
Research Abstract

We established the human vitreous tissue-derived cell strain to investigate the relationship between vitreous derived cells and intraocular proliferative diseases. Inflammatoly cytokines increased in intraocular proliferative diseases induced the hyaluronan production regulation on porcine vitreous derived cells. These cells also enhance the proliferation of the vascular endothelial cells on co-culture system.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Association of PDGF-BB-induced thrombomodulin with the regulation of inflammation in the corneal and scleral stroma.2010

    • Author(s)
      Namba H, Kashiwagi Y, Nishitsuka K, Takamura H, Yamamoto T, Yamashita H.
    • Journal Title

      Invest Ophthalmol Vis Sci. 51(11)

      Pages: 5460-5469

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interactions between vitreous-derived cells and vascular endothelial cells in vitreoretinal diseases2010

    • Author(s)
      Tojo N, Kashiwagi Y, Nishitsuka K, Yamamoto S, Asao H, Sugawara N, Yamashita T, Yamamoto T, Yamashita H.
    • Journal Title

      Acta Ophthalmol. 88(5)

      Pages: 564-570

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines.2010

    • Author(s)
      Kashiwagi Y, Kato N, Sassa T, Nishitsuka K, Yamamoto T, Takamura H, Yamashita H.
    • Journal Title

      Mol Vis. 16

      Pages: 970-982

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 増殖因子によるヒアルロナン代謝の調節2010

    • Author(s)
      西塚弘一
    • Journal Title

      あたらしい眼科 27巻

      Pages: 1415-1416

    • NAID

      10028246372

    • Related Report
      2010 Final Research Report
  • [Journal Article] 眼科医にもわかる生理活性物質と眼疾患の基本TGF-β2010

    • Author(s)
      西塚弘一
    • Journal Title

      臨床眼科 64巻

      Pages: 2020-2023

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines.2010

    • Author(s)
      Kashiwagi Y, Kato N, Sassa T, Nishitsuka K, Yamamoto T, Takamura H, Yamashita H.
    • Journal Title

      Mol Vis.

      Volume: 16 Pages: 970-982

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of PDGF-BB-induced thrombomodulin with the regulation of inflammation in the corneal and scleral stroma.2010

    • Author(s)
      Namba H, Kashiwagi Y, Nishitsuka K, Takamura H, Yamamoto T, Yamashita H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 5460-5469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 増殖因子によるヒアルロナン代謝の調節2010

    • Author(s)
      西塚弘一
    • Journal Title

      あたらしい眼科

      Volume: 27 Pages: 1415-1416

    • NAID

      10028246372

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 眼科医にもわかる生理活性物質と眼疾患の基本TGF-β2010

    • Author(s)
      西塚弘一
    • Journal Title

      臨床眼科

      Volume: 64 Pages: 2020-2023

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Cloning and characterization of human vitreous tissue-derived cells2010

    • Author(s)
      Kashiwagi Y, Nishitsuka K, Takamura H, Yamamoto T, Yamashita H
    • Journal Title

      Acta Ophthalmologica Scandinavica

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and characterization of human vitreous tissue-derived cells2009

    • Author(s)
      Kashiwagi Y, Nishitsuka K, Takamura H, Yamamoto T, Yamashita H
    • Journal Title

      Acta Ophthalmol.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interactions between vitreous-derived cells and vascular endothelial cells in vitreoretinal diseases2009

    • Author(s)
      Tojo N, Kashiwagi Y, Nishitsuka K, Yamamoto S, Asao H, Sugawara N, Yamashita T, Yamamoto T, Yamashita H.
    • Journal Title

      Acta Ophthalmologica Scandinavica

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Peripapillary Detachment in Pathogenic Myopiaに対する硝子体手術の長期経過2010

    • Author(s)
      西塚弘一、山本禎子、山下英俊
    • Organizer
      第64回日本臨床眼科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Intraoperative fluoroscopy-guided removal of the orbital foreign body in patient with penetrating ocular injury.: a case report.2010

    • Author(s)
      Nishitsuka K, Konno N, Takamura H, Yamamoto T, Yamashita H.
    • Organizer
      25th Asia Pacific Academy of Ophthalmology
    • Place of Presentation
      Beijing(中国)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effect of tumor necrosis factor-alpha on hyaluronan production and cell proliferation by porcine vitreous derived cell line.2010

    • Author(s)
      Nishitsuka K, Kashiwagi Y, Kaneko Y, Yamamoto T, Heldin P, Yamashita H.
    • Organizer
      8th International Conference on Hyaluronan
    • Place of Presentation
      京都
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Immortalization of Several Human Eye-Derived Cells Using Human Papilloma Virus 16 E6 and E7.2010

    • Author(s)
      Nishitsuka K, Kashiwagi Y, Kanno C, Yamamoto T, Takamura H, Yamashita H.
    • Organizer
      83st The Association for Research in Vision and Ophthalmology Annual meeting
    • Place of Presentation
      Fort Lauderdale(アメリカ)
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト眼組織由来不死化線維芽細胞株の性質について2010

    • Author(s)
      西塚弘一、柏木佳子、菅野智華子、山本禎子、高村浩、山下英俊
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 視力予後が良好であった網膜細動脈瘤破裂後の黄斑部出血に合併した黄斑円孔の1例2010

    • Author(s)
      西塚弘一、山本禎子、山下英俊
    • Organizer
      第34回日本眼科手術学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-01-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト硝子体組織由来cellstrainの樹立とブタ硝子体組織由来細胞株との比較検討2009

    • Author(s)
      西塚弘一
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト硝子体組織由来 cell strain の樹立とブタ硝子体組織由来細胞株との比較検討2009

    • Author(s)
      西塚弘一, ほか
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2009 Annual Research Report
  • [Remarks] 山形大学研究者情報

    • URL

      http://yudb.kj.yamagata-u.ac.jp/OUTSIDE?ISTActId=SCHKOB0010RIni001&userId=100000187&lang_kbn=0

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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