Role of lipofuscin on retinal pigment epithelial cells and Bruch's membrane

• Project/Area Number: 21791669
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: YANAGI Yasuo The University of Tokyo, 医学部附属病院, 助教 (90376442)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: リポフスチン / 網膜色素上皮

Research Abstract

Role of lipofuscin on retinal pigment epithelial cells and Bruch's membraneRole of lipofuscin in retinal pigment epithelium

Research Products

• [Journal Article] Utility values in Japanese patients with exudative age-related macular degeneration. (2011)
  • Author(s): Yanagi Y, Ueta T, Obata R, Iriyama A, Fukuda T, Hashimoto H.
  • Journal Title: Jpn J Ophthalmol 55 Pages: 35-38
  • NAID: 10029020533
  • Peer Reviewed
• [Journal Article] Nerve fiber layer thickness in exudative age-related macular degeneration in Japanese patients. (2009)
  • Author(s): Yuda K, Inoue Y, Tomidokoro A, Tamaki Y, Yanagi Y.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol (epub ahead of print)
  • Peer Reviewed
• [Journal Article] Cerebrovascular accidents in ranibizumab. (2009)
  • Author(s): Ueta T, Yanagi Y, Tamaki Y, Yamaguchi T.
  • Journal Title: Ophthalmology 116 Pages: 362-362
  • Peer Reviewed
• [Journal Article] Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients. (2009)
  • Author(s): Ueta T, Obata R, Inoue Y, Iriyama A, Takahashi H, Yamaguchi T, Tamaki Y, Yanagi Y.
  • Journal Title: Ophthalmology 116 Pages: 2400-2406
  • Peer Reviewed
• [Journal Article] A case of vasoproliferative retinal tumor treated by transpupillary thermotherapy. (2009)
  • Author(s): Nomura Y, Tamaki Y, Tsuji H, Kojima H, Yanagi Y.
  • Journal Title: Retinal Cases & Brief Reports 3 Pages: 358-360
  • Peer Reviewed
• [Journal Article] A2E, a component of lipofuscin, is pro-angiogenic in vivo. (2009)
  • Author(s): Iriyama A, Inoue Y, Takahashi H, Tamaki Y, Jang WD, Yanagi Y.
  • Journal Title: J Cell Physiol 220 Pages: 469-475
  • Peer Reviewed
• [Journal Article] A2E, a component of lipofuscin, is pro-angiogenic in vivo (2009)
  • Author(s): Iriyama A, Inoue Y, Takahashi H, Tamaki Y, Jang WD, Yanagi Y
  • Journal Title: J Cell Physiol 220 Pages: 469-75
  • Peer Reviewed
• [Journal Article] Gene Transfer using Micellar Nanovectors inhibits Corneal Neovascularization in vivo.
  • Author(s): Iriyama A, Usui T, Yanagi Y, Amano S, Oba M, Miyata K, Nishiyama N, Kataoka K.
  • Journal Title: Cornea in press
  • Peer Reviewed
• [Journal Article] Vitreomacular interface in typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy.
  • Author(s): Nomura Y, Ueta T, Iriyama A, Inoue Y, Obata R, Tamaki Y, Yamaguchi T, Yanagi Y.
  • Journal Title: Ophthalmology in press
  • Peer Reviewed
• [Journal Article] A case of vitreopapillary traction diagnosed by spectral-domain optical coherence tomography, Ophthalmic Surgery, Lasers & Imaging
  • Author(s): Nomura Y, Tamaki Y, Yanagi Y.
  • Journal Title: in press
  • Peer Reviewed
• [Presentation] 網脈絡膜新生血管のメカニズム, 学会合同シンポジウム「抗血管新生治療-基礎と臨床-」 (2009)
  • Author(s): 柳靖雄
  • Organizer: NOW2009(48網膜・26眼循環・15糖尿病眼 合同学会)
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-05
• [Presentation] 加齢黄斑変性のドラッグデリバリーシステムの現状と今後, シンポジウム「眼科領域におけるドラッグデリバリーシステムのアップデート」 (2009)
  • Author(s): 柳靖雄
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-11
• [Presentation] 抗血管新生薬剤の種類, シンポジウム「抗血管新生治療の適応と実際」 (2009)
  • Author(s): 柳靖雄
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-10
• [Presentation] 脈絡膜新生血管:VEGFとその受容体を標的とした治療, シンポジウム「抗血管新生治療の新戦略 -血管細胞生物学からのアプローチ」 (2009)
  • Author(s): 柳靖雄
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-18
• [Presentation] 脈絡膜新生血管:VEGFとその受容体を標的とした治療, シンポジウム「抗血管新生治療の新戦略-血管細胞生物学からのアプローチ」 (2009)
  • Author(s): 柳靖雄
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-18
• [Presentation] 網脈絡膜新生血管のメカニズム, 学会合同シンポジウム「抗血管新生治療-基礎と臨床-」 (2009)
  • Author(s): 柳靖雄
  • Organizer: NOW2009 (48網膜・26眼循環・15糖尿病眼 合同学会)
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-25