Development of detecting retinal ganglion cell response using electroretinogram
Project/Area Number |
21791678
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Nagoya University |
Principal Investigator |
UENO Shinji Nagoya University, 医学部附属病院, 助教 (80528670)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | ERG / retinal ganglion cell / PhNR / 網膜電図 / 網膜神経節細胞 / マウス / 軸索数 / 視神経障害モデル |
Research Abstract |
We studied detecting retinal ganglion cell response using ERG in animal models. We detected scotopic threshold response (STR) from -7.2 log cd s m^2 to -4.2 log cd s m^2. The amplitude of STR significantly decreased after optic nerve injury. These results indicated STR is originated from retinal ganglion cells. We also checked mouse photopic negative response (PhNR), which is supposed to be originated from retinal ganglion cells in primate. But our results did not show significant reduction of PhNR after tetrodotoxin injection in mouse eye. This result indicated PhNR of mouse is not useful to detect mouse retinal ganglion cell response. Rabbit ERG showed reduction of PhNR after TTX injection and these data showed PhNR of rabbit eye consisted of retinal ganglion cell function. The origin of PhNR may be different among animal species.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade2010
Author(s)
Koike, C.Obara, T.Uriu, Y.Numata, T.Sanuki, R.Miyata, K.Koyasu, T.Ueno, S.Funabiki, K.Tani, A.Ueda, H.Kondo, M.Mori, Y.Tachibana, M.Furukawa, T.
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Journal Title
Proc Natl Acad Sci USA 107
Pages: 332-337
Related Report
Peer Reviewed
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[Journal Article] Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa2009
Author(s)
Usui, S.Komeima, K.Lee, S.Y.Jo, Y.J.Ueno, S.Rogers, B.S.Wu, Z.Shen, J.Lu, L.Oveson, B.C.Rabinovitch, P.S.Campochiaro, P.A.
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Journal Title
Molcular Therapy 17
Pages: 778-786
Related Report
Peer Reviewed
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