Effect of prostaglandin analogues on contraction and degradation of collagen gel mediated by human scleral fibroblasts

Research Project

Project/Area Number	21791684
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Yamaguchi University
Principal Investigator	SUZUKI Katsuyoshi Yamaguchi University, 医学部附属病院, 講師 (90325217)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	強膜線維芽細胞 / PG F2 / collagen gel / PGF2α / Collagen gel / PG F2α
Research Abstract	Prostaglandin analogues improve uveoscleral outflow, but its mechanism and physiology of uveoscleral outflow are still unknown. In this study, prostaglandin analogues induced collagen gel contraction mediated by human scleral fibroblasts. This action of prostaglandin analogues appeared to depend on the formation of stress fibers as well as the activation of mitogen-activated protein kinase, focal adhesion kinase, Rho-associated kinase in human scleral fibroblasts. Prostaglandin analogues might therefore influence scleral structure by affecting the contractility of scleral fibroblasts, resulting in improvement of uveoscleral outflow.

Report

(3 results)