Development of rejection-free corneal transplantation using cultured corneal endothelial cell

• Project/Area Number: 21791698
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Yokohama City University
• Principal Investigator: HAYASHI Takahiko Yokohama City University, 医学研究科, 特別研究員 (20527931)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 眼免疫学

Research Abstract

To resolve severe worldwide shortage of donors, we established a mouse model in which cultured allocorneal endothelium was transplanted onto a recipient mouse cornea. During the follow-up period, the transplanted cultured allo-corneal endothelium did not show any sign of allograft rejection. Realization of the clinical application of cultured allo-corneal endothelium transplantation may be a shortcut to ideal rejection-free corneal transplantation.

Research Products

• [Journal Article] Immunologic mechanisms of corneal allografts reconstituted from cultured allogeneic endothelial cells in an immune-privileged site. (2009)
  • Author(s): Hayashi, T., Yamagami, S., Tanaka, K., Yokoo, S., Usui, T., Amano, S., Mizuki, N.
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 3151-3158
• [Journal Article] Immunologic Mechanisms of Corneal Allografts Reconstituted from Cult ured Allogeneic Endothelial Cells in an Immune-Privileged Site. (2009)
  • Author(s): 林孝彦
  • Journal Title: Investigative Ophthalmology & Visual Science 50 Pages: 3151-3158
  • Peer Reviewed