| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Hes1, a major target gene in Notch signaling, is essential for corneal and eye morphogenesis. Hes1 is mainly expressed in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provides the first evidence that Hes1 is essential for corneal morphogenesis and regulates the homeostatic function of corneal epithelial stem/progenitor cells.
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