Neuroprotective Effects of G-CSF on Ischemia-Reperfusion Injury of Retina

• Project/Area Number: 21791723
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kansai Medical University
• Principal Investigator: MINAMINO Keizo Kansai Medical University, 医学部, 助教 (40509585)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 緑内障 / G-CSF / 神経保護 / アポトーシス / 虚血再灌流モデル / 神経保護効果 / TUNEL染色 / ウエスタンブロット / 抗アポトーシス / AKTのリン酸化 / 緑内障モデルマウス / 虚血再還流障害 / 抗アポトーシス因子

Research Abstract

It has been reported that granulocyte colony-stimulating factor (G-CSF) provides neuroprotection in models inducing neuronal cell death. The present study was designed to investigate the effects of G-CSF on neurodegeneration of the inner retinal layer in a rat model of ischemic-reperfusion (I/R) injury. In conclusion, our results demonstrated that the systemic injection of G-CSF can protect retinal ganglion cells (RGC) and inner retinal layers from I/R injury. The effects could be associated with the activation of AKT.

Research Products

• [Journal Article] 診断に苦慮したLeber遺伝性視神経症の1例 (2011)
  • Author(s): 南野桂三, 安藤彰, 竹内正光, 高橋寛二, 小池直子, 小林かおる, 秋岡真砂子, 河合江実, 白紙靖之, 森秀夫, 西村哲哉
  • Journal Title: あたらしい眼科 28 Pages: 139-143
  • NAID: 10028247473
  • Peer Reviewed
• [Journal Article] 診断に苦慮したLeber遺伝性視神経症の1例 (2011)
  • Author(s): 南野桂三、安藤彰、竹内正光, 他
  • Journal Title: あたらしい眼科 Volume: 28 Pages: 139-143
  • NAID: 10028247473
  • Peer Reviewed
• [Journal Article] Soemmering輪による続発閉塞隅角緑内障の1例 (2010)
  • Author(s): 松山加耶子, 南野桂三, 安藤彰, 竹内正光, 和田光正, 嶋千絵子, 松岡雅人, 福井智恵子, 桑原敦子, 松山英子, 西村哲哉
  • Journal Title: あたらしい眼科 27 Pages: 1603-1606
  • NAID: 10028246764
  • Peer Reviewed
• [Journal Article] Soemmering輪による続発閉塞隅角緑内障の1例 (2010)
  • Author(s): 松山加耶子、南野桂三、安藤彰, 他
  • Journal Title: あたらしい眼科 Volume: 27 Pages: 1603-1606
  • NAID: 10028246764
  • Peer Reviewed
• [Journal Article] Abnormal distribution of dendritic cells in (NZW x BXSB)F1 mice. (2009)
  • Author(s): Tokuyama Y, Adachi Y, Minamino K, Shintaku H, Okigaki M, Hayashi K, Kitajima A, Takaki T, Koike N, Shima C, Imai Y, Shi M, Yanai S, Ikehara S
  • Journal Title: Autoimmunity 42(5) Pages: 399-405
  • Peer Reviewed
• [Journal Article] The combination method using magnetic beads and a magnet helps sustain the number of donor BM cells after intra-BM injection, resulting in rapid hematopoietic recovery. (2009)
  • Author(s): Shima C, Adachi Y, Shi M, Imai Y, Okigaki M, Yanai S, Minamino K, Takahashi K, Ikehara S
  • Journal Title: Bone Marrow Transplant 45(6) Pages: 993-999
  • Peer Reviewed
• [Journal Article] Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. (2009)
  • Author(s): Ikeda K, Nakano R, Uraoka M, Nakagawa Y, Koide M, Katsume A, Minamino K, Yamada E, Yamada H, Quertermous T, Matsubara H
  • Journal Title: Proc Natl Acad Sci USA 106(20) Pages: 8227-8232
  • Peer Reviewed
• [Journal Article] 選択的レーザー線維柱帯形成術の治療成績 (2009)
  • Author(s): 南野桂三, 松岡雅人, 安藤彰, 松山加耶子, 嶋千絵子, 福井智恵子, 桑原敦子, 尾辻剛, 緒方奈保子, 西村哲哉
  • Journal Title: あたらしい眼科 26 Pages: 1249-1252
  • NAID: 10027069446
  • Peer Reviewed
• [Journal Article] Abnormal distribution of dendritic cells in(NZW x BXSB)F1 mice (2009)
  • Author(s): Tokuyama Y, Adachi Y, Minamino K et al
  • Journal Title: Autoimmunity 42 Pages: 399-405
  • Peer Reviewed
• [Journal Article] 選択的レーザー線維柱帯形成術の治療成績 (2009)
  • Author(s): 南野桂三、松岡雅人、安藤彰, 他
  • Journal Title: あたらしい眼科 26 Pages: 1249-1252
  • NAID: 10027069446
  • Peer Reviewed
• [Journal Article] The combination method using magnetic beads and a magnet helps sustain the number of donor BM cells after intra-BM injection, resulting in rapid hematopoietic recovery (2009)
  • Author(s): Shima C, Adachi Y, Shi M et al
  • Journal Title: Bone Marrow Transplantation (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 白内障術後強膜創からの前房水漏出による低眼圧黄斑症の1例 (2011)
  • Author(s): 南野桂三
  • Organizer: 第34回日本眼科手術学会総会
  • Place of Presentation: 京都国際会議場(京都市左京区)
  • Year and Date: 2011-01-28
• [Presentation] 白内障術後強膜創からの前房水漏出による低眼圧黄斑症の1例 (2011)
  • Author(s): 南野桂三
  • Organizer: 第34回日本眼科手術学会総会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2011-01-28
• [Presentation] ラタノプロストからトラボプロストへの切り替えによる眼圧下降効果 (2010)
  • Author(s): 南野桂三
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市熱田区)
  • Year and Date: 2010-04-15
• [Presentation] 診断に苦慮したLeber遺伝性視神経症の1例 (2009)
  • Author(s): 南野桂三
  • Organizer: 第47回日本神経眼科学会総会
  • Place of Presentation: 日経ホール(東京都千代田区)
  • Year and Date: 2009-11-13
• [Presentation] 診断に苦慮した Leber 遺伝性視神経症の1例 (2009)
  • Author(s): 南野桂三
  • Organizer: 第47回日本神経眼科学会総会
  • Place of Presentation: 日経ホール(東京都千代田区)
  • Year and Date: 2009-11-13