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Cerebral alteration in patients with glaucoma

Research Project

Project/Area Number 21791725
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

SUZUKI Yukihisa  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (00415506)

Co-Investigator(Renkei-kenkyūsha) ISHII Kenji  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所付属診療所, 診療所長 (10231135)
ISHIWATA Kiichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所付属診療所, 施設長 (50143037)
ODA Keiichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所付属診療所, 研究員 (70224235)
TOKUMARU Aya  地方独立行政法人東京都健康長寿医療センター, 放射線診療科, 部長
MURAI Hideki  東京医科歯科大学, 大学院・眼科, 大学院生
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords緑内障 / MRI / ポジトロン断層法(PET) / ポジトロン断層法 / 視放線
Research Abstract

We studied 27 patients with glaucoma and 14 normal controls by using magnetic resonance imaging (MRI) and positron emission tomography. In MRI analysis, optic radiation was injured in patients with glaucoma. We observed that glucose hypometabolism in bilateral striate cortex in patients with glaucoma, and there was a correlation between glucose metabolism of striate cortex and severity of glaucoma. These results indicate that glaucoma causes alterations in the brain.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (3 results)

  • [Journal Article] Gray matter density increase in the primary sensorimotor cortex in long-term essential blepharospasm.2011

    • Author(s)
      Suzuki Y, Kiyosawa M, Wakakura M, Mochizuki M, Ishii K.
    • Journal Title

      Neuro Image. 56

      Pages: 1-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positive correlation between severity of blepharospasm and thalamic glucose metabolism.2011

    • Author(s)
      Murai H, Suzuki Y, Kiyosawa M, Wakakura M, Mochizuki M, Ishiwata K, Ishii K.
    • Journal Title

      Case Report Ophthalmol. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pre-supplementary and primary motor areas generate rhythm for voluntary eye opening and closing movements.2010

    • Author(s)
      Suzuki Y, Kiyosawa M, Mochizuki M, Ishiwata K, Ishii K.
    • Journal Title

      Tohoku J Exp Med. 222

      Pages: 97-104

    • NAID

      10027085790

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photophobia in essential blepharospasm- A positron emission tomographic study.2010

    • Author(s)
      Emoto H, Suzuki Y, Wakakura M, Horie C, Kiyosawa M, Mochizuki M, Kawasaki K, Oda K, Ishiwata K, Ishii K.
    • Journal Title

      Mov Disord. 25

      Pages: 433-439

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pre-supplementary and primary motor areas generate rhythm for voluntary eye opening and closing movements.2010

    • Author(s)
      Suzuki Y, Kiyosawa M, Mochizuki M, Ishiwata K, Ishii K.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 222 Pages: 97-104

    • NAID

      10027085790

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photophobia in essential blepharospasm- A positron emission tomographic study.2010

    • Author(s)
      Emoto H, Suzuki Y, Wakakura M, Horie C, Kiyosawa M, Mochizuki M, Kawasaki K, Oda K, Ishiwata K, Ishii K.
    • Journal Title

      Mov Disord.

      Volume: 25 Pages: 433-439

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床と研究の接点、同名半盲とPET2009

    • Author(s)
      鈴木幸久
    • Journal Title

      神経眼科 26

      Pages: 413-417

    • Related Report
      2010 Final Research Report
  • [Journal Article] Functional and neuroreceptor imaging of the brain in bicuculline-induced dystonic rats.2009

    • Author(s)
      Qing GeLe Tu, Suzuki Y, Kiyosawa M, Ishiwata K, Mochizuki M.
    • Journal Title

      Tohoku J Exp Med. 217

      Pages: 313-20

    • NAID

      10025105694

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased dopamine D receptor binding in essential blepharospasm.2009

    • Author(s)
      Horie C, Suzuki Y, Kiyosawa M, Mochizuki M, Wakakura M, Oda K, Ishiwata K, Ishii K.
    • Journal Title

      Acta Neurol Scand. 119

      Pages: 49-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床と研究の接点、同名半盲とPET2009

    • Author(s)
      鈴木幸久
    • Journal Title

      神経眼科 26巻

    • Related Report
      2009 Annual Research Report
  • [Presentation] 原発性眼瞼痙攣患者の脳内変化2011

    • Author(s)
      鈴木幸久
    • Organizer
      第4回TMD眼科フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 緑内障患者群にみられた一次視覚野における脳糖代謝低下2010

    • Author(s)
      村井秀樹、鈴木幸久、清澤源弘、望月學、石渡喜一、石井賢二
    • Organizer
      第48回日本神経眼科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] 眼瞼痙攣の重症度と視床の糖代謝との間に相関関係がみられた一例2009

    • Author(s)
      村井秀樹、鈴木幸久、清水恵、清澤源弘、望月學、若倉雅登、石井賢二
    • Organizer
      第47回日本神経眼科学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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