• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Construction of scaffold-free tracheal cartilage using sell sheet-based tissue engineering and dynamic culture

Research Project

Project/Area Number 21791730
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionOsaka University

Principal Investigator

TANI Gakuto  Osaka University, 医学部附属病院, 医員 (60467561)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords再生医療 / 軟骨再生 / 細胞シート / 回転培養 / 再生医学
Research Abstract

Auricular chondrocytes were harvested from New Zealand white rabbits and cultivated to form a chondrocyte sheet. The sheet was looped around a silicon tube and cultivated in dynamic conditions. Engineered cartilage maintained the shape and a proper level of rigidity and flexibility, under in vitro conditions. Glycosaminoglycans content of the engineered cartilage corresponded approximately to the content of the rabbit auricular cartilage. Engineered cartilage was easy to convert the cylindrical cartilage into serial ring cartilages by slicing. The graft of engineered cartilage maintained a cylindrical shape, and was elastic and stiff. But, the GAG content of the graft was significantly decreased.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] In vitro construction of scaffold-free cylindrical cartilage using cell sheet-based tissue engineering.2010

    • Author(s)
      Gakuto Tani, Noriaki Usui, Masafumi Kamiyama, Takaharu Oue, Masahiro Fukuzawa
    • Journal Title

      Pediatric Surgery International Vol.26

      Pages: 179-185

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児外科における再生医療-足場を用いない気管軟骨再生の試みと境界領域としての臓器再建医療-2010

    • Author(s)
      谷岳人、臼井規朗、神山雅史、福澤正洋
    • Journal Title

      日本周産期・新生児医学会雑誌 46巻

      Pages: 993-996

    • NAID

      10027853353

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小児外科における再生医療-足場を用いない気管軟骨再生の試みと境界領域としての臓器再建医療-2010

    • Author(s)
      谷岳人
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 46 Pages: 993-996

    • NAID

      10027853353

    • Related Report
      2010 Annual Research Report
  • [Journal Article] In vitro construction of scaffold-free cylindrical cartilage using cell sheet-based tissue engineering2010

    • Author(s)
      Gakuto Tani, Noriaki Usui, Masafumi Kamiyama, Takaharu Oue, Masahiro Fukuzawa
    • Journal Title

      Pediatric Surgery International 26

      Pages: 179-185

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tissue engineering of tracheal cartilage : Scaffold-free carltilaginous constructs using cell sheet-based tissue engineering2010

    • Author(s)
      Gakuto Tani
    • Organizer
      Annual Meeting of the German Society of Paediatric and Adolescent Medicine
    • Place of Presentation
      Filmpark Babelsberg (Germany)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Tissue engineering of tracheal cartilage : Scaffold-free carltilaginous constructs using cell sheet-based tissue engineering2010

    • Author(s)
      谷岳人
    • Organizer
      Annual Meeting of the German Society of Paediatric and Adolescent Medicine
    • Place of Presentation
      Filmpark Babelsberg (Potsdam, Germany)(招待講演)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児外科における再生医療2-足場を用いない気管軟骨再生の試みと境界領域としての臓器再建医療-2010

    • Author(s)
      谷岳人
    • Organizer
      日本周産期・新生児医学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-07-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児外科における再生医療2-足場を用いない気管軟骨再生の試みと境界領域としての臓器再建医療-2010

    • Author(s)
      谷岳人
    • Organizer
      日本周産期・新生児医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨細胞シートを応用した気管軟骨再生法の開発2010

    • Author(s)
      谷岳人
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 軟骨細胞シートを応用した気管軟骨再生法の開発2010

    • Author(s)
      谷岳人
    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨細胞シートを応用したin vitroにおける気管軟骨再生法の開発2009

    • Author(s)
      谷岳人
    • Organizer
      日本小児外科学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 軟骨細胞シートを応用したin vitroにおける気管軟骨再生法の開発2009

    • Author(s)
      谷岳人
    • Organizer
      日本小児外科学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi