A clarification of the mechanism that B cell tolerance induced by liver sinusoidal endothelial cells and application to the clinical treatment against humoral rejection.

• Project/Area Number: 21791731
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: Hiroshima University
• Principal Investigator: IGARASHI Yuka 広島大学, 大学院・医歯薬学総合研究科, 研究員 (10531692)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 移植・再生医療 / 糖鎖 / 免疫 / 外科 / トランスレーショナルリサーチ / 移植再生医療 / 糖鎖抗原 / 免疫学 / 肝類同内皮細胞 / PDL-1分子 / 肝類洞内皮細胞

Research Abstract

We have recently shown that B cells tolerance to donor blood group-A antigens develops following blood group A-to-O pediatric liver transplantation. Blood group antigen-reactive B cells might be tolerized through their interaction with liver sinusoidal endothelial cells(LSECs), which exclusively express blood group antigens together with PDL-1.

Research Products

• [Presentation] 肝類洞内皮細胞はPD-1/ PDL-1 pathwayを介して抗原特異的免疫寛容を誘導する (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第18回肝細胞研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-24
• [Presentation] 肝類洞内皮細胞はPD-1/PDL-1 pathwayを介して抗原特異的免疫寛容を誘導する (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第18回肝細胞研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-24
• [Presentation] 肝類洞内皮細胞はPD-1/ PDL-1 pathwayを介してB細胞の抗原特異的抗体産生を抑制する (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
• [Presentation] 糖鎖抗原を表出した肝類洞内皮細胞はPD-1/ PDL-1 pathwayを介してB細胞の抗原特異的抗体産生を抑制できる (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第29回日本肝移植研究会
  • Place of Presentation: 仙台
• [Presentation] Liver sinusoidal endothe lial cells expressing carbohydrates render reactive immature B cellstolerant through PD-1/ PDL-1 pathway (2011)
  • Author(s): Yuka Igarashi
  • Organizer: American Transplantation congress
  • Place of Presentation: Philadelphia. USA
• [Presentation] Liver sinusoidal endothelial cells expressing carbohydrates render reactive immature B cells tolerant through PD-1/PDL-1 pathway (2011)
  • Author(s): Yuka Igarashi
  • Organizer: American Transplantation congress 2011
  • Place of Presentation: Philadelphia USA
• [Presentation] 糖鎖抗原を表出した肝類洞内皮細胞はPD-1/PDL-1 pathwayを介してB細胞の抗原特異的抗体産生を抑制できる (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第29回日本肝移植研究会
  • Place of Presentation: 仙台
• [Presentation] 肝類洞内皮細胞はPD-1/PDL-1 pathwayを介してB細胞の抗原特異的抗体産生を抑制する (2011)
  • Author(s): 五十嵐友香
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
• [Presentation] 肝類洞内皮細胞による血液型抗原認識B細胞の寛容化においてFas-FasL pathwayは主要な役割を果たさない (2010)
  • Author(s): 五十嵐友香
  • Organizer: 第17回ABO血液型不適合移植研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-31
• [Presentation] Liver Sinusoidal Endothelial Cells expressing Carbohydrates Render Reactive B cells Tolerant (2010)
  • Author(s): Yuka Igarashi, Toshimitu Irei, Hideki Ohdan
  • Organizer: XXIIIInternational Congress of thetransplantation
  • Place of Presentation: Vancouver. Canada
• [Presentation] 糖鎖抗原を表出した肝類洞内皮細胞はB細胞の抗体産生を抑制できる (2010)
  • Author(s): 五十嵐友香
  • Organizer: 第28回日本肝移植研究会 一般演題
  • Place of Presentation: 広島
• [Presentation] Liver Sinusoidal Endothelial Cells expressing Carbohydrates Render Reactive B cells Tolerant (2010)
  • Author(s): Yuka Igarashi
  • Organizer: International Transplantation Congerss 2010
  • Place of Presentation: バンクーバー(カナダ)
• [Presentation] 糖鎖抗原を表出した肝類洞内皮細胞は応答するB細胞を特異的に抑制する (2010)
  • Author(s): 五十嵐友香
  • Organizer: 第46回日本移植学会 一般演題
  • Place of Presentation: 京都
• [Presentation] Liver Sinusoidal Endothelial Cells Toleriza B cells Specific for Blood Group Carbohydrate Antigens after ABO-incompatible Liver Transplantation (2009)
  • Author(s): 五十嵐友香
  • Organizer: Europena Society for Organ Transplantation 2009
  • Place of Presentation: France, Pari
  • Year and Date: 2009-08-31
• [Presentation] Masataka Bansyodani, Toshimitu Irei, Yuka Tanaka, HidekiOhdan. Liver Sinusoidal EndothelialCells Tolerize B cells Specific forBlood Group Carbohydrate Antigensafter ABO-incompatible LiverTransplantation (2009)
  • Author(s): Yuka Igarashi
  • Organizer: France, paris
  • Place of Presentation: France, paris
• [Book] ABO血液型不適合移植の新戦略p38-p43 (2011)
  • Author(s): 高橋公太、田中紘一
  • Total Pages: 71
  • Publisher: 日本医学館
• [Book] ABO血液型不適合移植の新戦略2011 (2011)
  • Author(s): 五十嵐友香
  • Publisher: 日本医学館(印刷中)
• [Book] ABO血液型不適合移植の新戦略ABO血液型不適合移植の新戦略2011
  • Author(s): 高橋公太
  • Publisher: 日本医学館