SNParray analysis for the tailor maid treatment of the solid malignant tumor in children

• Project/Area Number: 21791733
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: Kyushu University
• Principal Investigator: TANAKA Sakura Kyushu University, 医学研究院 (40467923)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: テーラーメード型治療 / SNP array / 癌 / 外科 / ゲノム / 小児 / 小児固形悪性腫瘍 / 神経芽腫 / 肝芽腫 / Wilms腫瘍 / MYCN遺伝子 / 2p gain

Research Abstract

We determined the status of 2p region of neuroblastomas by SNP array. The MYCN gene which is the strongest prognostic factor of the neuroblastoma is located at 2p region. we revealed that the state of the 2p region affect the prognosis of neuroblastoma patients.

Research Products

• [Journal Article] Concordance for neuroblastoma in monozygotic twins : Case report and review of the literature (2010)
  • Author(s): Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T
  • Journal Title: J Pediatr Surg 45巻 Pages: 2312-2316
  • Peer Reviewed
• [Journal Article] 神経芽腫の治療-外科的立場から- (2010)
  • Author(s): 田尻達郎、木下義晶、宗崎良太、田中桜、東真弓、孝橋賢一、田口智章
  • Journal Title: 小児がん 47巻 Pages: 40-45
  • NAID: 110007575315
  • Peer Reviewed
• [Journal Article] 神経芽腫の治療-外科的立場から- (2010)
  • Author(s): 田尻達郎、木下義晶、宗崎良太、田中桜、東真弓、孝橋賢一、田口智章
  • Journal Title: 小児がん 47 Pages: 40-45
  • NAID: 110007575315
  • Peer Reviewed
• [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japanl (2009)
  • Author(s): Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T
  • Journal Title: J Pediatr Surg 44巻 Pages: 2253-2257
  • Peer Reviewed
• [Journal Article] Sustained and NK/CD4+ T Cell-Dependent Efficient Prevention of Lung Metastasis Induced by Dendritic Cells Harboring Recombinant Sendai Virus (2009)
  • Author(s): Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, Kinoh H, Harada Y, Suzuki H, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y
  • Journal Title: The Journal of Immunology 183 Pages: 4211-4219
  • Peer Reviewed
• [Journal Article] Efficient protective immunity against Trypanosoma cruzi infection after nasal vaccination with recombinant Sendai virus vector expressing amastigote surface protein-2 (2009)
  • Author(s): Duan X, Yonemitsu Y, Chou B, Yoshida K, Tanaka S, Hasegawa M, Tetsutani K, Ishida H, Himeno K, Hisaeda H
  • Journal Title: Vaccine 27 Pages: 6154-6159
  • Peer Reviewed
• [Journal Article] Complete Elimination of Established Neuroblastoma by Synergistic Action of g-Irradiation and DCs Treated with rSeV expressing Interferon-b Gene (2009)
  • Author(s): Tatsuta K, Tanaka S, Tajiri T, Shibata S, Komaru A, Ueda Y, Inoue M, Hasegawa M, Suita S, Sueishi K, Taguchi T, Yonemitsu Y
  • Journal Title: Gene Therapy 16巻 Pages: 240-251
  • Peer Reviewed
• [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japan. (2009)
  • Author(s): Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T.
  • Journal Title: J Pediatr Surg. 44 Pages: 2253-2257
  • Peer Reviewed
• [Presentation] 神経芽腫に対する放射線併用新規免疫遺伝子治療の開発 (2010)
  • Author(s): 田中桜
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-12-18
• [Presentation] 神経芽腫におけるFISH法によるMYCN gain とSNP array による2p gain の検討 (2009)
  • Author(s): 宗崎良太, 田尻達郎, 田中桜, 木下義晶, 田口智章
  • Organizer: 第46回日本小児外科学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2009-06-01
• [Presentation] 神経芽腫におけるFISH法によるMYCN gainとSNP arrayによる2p gainの検討 (2009)
  • Author(s): 宗崎良太田尻達郎, 田中桜, 木下義品, 田口智章
  • Organizer: 第46回日本小児外科学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-06-01
• [Remarks] ホームページ等