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SNParray analysis for the tailor maid treatment of the solid malignant tumor in children

Research Project

Project/Area Number 21791733
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

TANAKA Sakura  Kyushu University, 医学研究院 (40467923)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsテーラーメード型治療 / SNP array / 癌 / 外科 / ゲノム / 小児 / 小児固形悪性腫瘍 / 神経芽腫 / 肝芽腫 / Wilms腫瘍 / MYCN遺伝子 / 2p gain
Research Abstract

We determined the status of 2p region of neuroblastomas by SNP array. The MYCN gene which is the strongest prognostic factor of the neuroblastoma is located at 2p region. we revealed that the state of the 2p region affect the prognosis of neuroblastoma patients.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Concordance for neuroblastoma in monozygotic twins : Case report and review of the literature2010

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Hara T, Kohashi K, Oda Y, Masumoto K, Ohira M, Nakagawara A, Taguchi T
    • Journal Title

      J Pediatr Surg 45巻

      Pages: 2312-2316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経芽腫の治療-外科的立場から-2010

    • Author(s)
      田尻達郎、木下義晶、宗崎良太、田中桜、東真弓、孝橋賢一、田口智章
    • Journal Title

      小児がん 47巻

      Pages: 40-45

    • NAID

      110007575315

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経芽腫の治療-外科的立場から-2010

    • Author(s)
      田尻達郎、木下義晶、宗崎良太、田中桜、東真弓、孝橋賢一、田口智章
    • Journal Title

      小児がん 47

      Pages: 40-45

    • NAID

      110007575315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japanl2009

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T
    • Journal Title

      J Pediatr Surg 44巻

      Pages: 2253-2257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sustained and NK/CD4+ T Cell-Dependent Efficient Prevention of Lung Metastasis Induced by Dendritic Cells Harboring Recombinant Sendai Virus2009

    • Author(s)
      Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, Kinoh H, Harada Y, Suzuki H, Inoue M, Hasegawa M, Ichikawa T, Yonemitsu Y
    • Journal Title

      The Journal of Immunology 183

      Pages: 4211-4219

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient protective immunity against Trypanosoma cruzi infection after nasal vaccination with recombinant Sendai virus vector expressing amastigote surface protein-22009

    • Author(s)
      Duan X, Yonemitsu Y, Chou B, Yoshida K, Tanaka S, Hasegawa M, Tetsutani K, Ishida H, Himeno K, Hisaeda H
    • Journal Title

      Vaccine 27

      Pages: 6154-6159

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete Elimination of Established Neuroblastoma by Synergistic Action of g-Irradiation and DCs Treated with rSeV expressing Interferon-b Gene2009

    • Author(s)
      Tatsuta K, Tanaka S, Tajiri T, Shibata S, Komaru A, Ueda Y, Inoue M, Hasegawa M, Suita S, Sueishi K, Taguchi T, Yonemitsu Y
    • Journal Title

      Gene Therapy 16巻

      Pages: 240-251

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japan.2009

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T.
    • Journal Title

      J Pediatr Surg. 44

      Pages: 2253-2257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経芽腫に対する放射線併用新規免疫遺伝子治療の開発2010

    • Author(s)
      田中桜
    • Organizer
      第26回日本小児がん学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 神経芽腫におけるFISH法によるMYCN gain とSNP array による2p gain の検討2009

    • Author(s)
      宗崎良太, 田尻達郎, 田中桜, 木下義晶, 田口智章
    • Organizer
      第46回日本小児外科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-06-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経芽腫におけるFISH法によるMYCN gainとSNP arrayによる2p gainの検討2009

    • Author(s)
      宗崎良太田尻達郎, 田中桜, 木下義品, 田口智章
    • Organizer
      第46回日本小児外科学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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