Regeneration of Interstitial cells of Cajal for gastrointestinal motility disorder.
| Project/Area Number |
21791735
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Keio University |
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Principal Investigator |
MORI Masaharu 慶應義塾大学, 医学部, 助教 (00445389)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | カハール / 腸管運動 / 再生 / 間葉系幹細胞 / 移植 / 共培養 / 形態学 |
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| Research Abstract |
Interstitial cells of Cajal(ICC) that work as pacemaker cells in gut play important roles in autonomic gut motility as well as intestinal smooth muscles and nerves. It has been reported that the number of ICC is decreased in various conditions such as Hirschsprung's disease, diabetes mellitus, and imflammatory bowel disease. It is expected that regeneration of ICC improve gut motility in such conditions. In this study, we succeeded to differentiate murine bone marrow mesenchymal stem cells into cells that were morphologically compatible with ICC in either optical and electron microscopy.
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Report
(4 results)
Research Products
(6 results)
