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Development of cultured cell-transplantation for hair regeneration therapy.

Research Project

Project/Area Number 21791738
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

IIDA Takuya  The University of Tokyo, 医学部附属病院, 助教 (00398603)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords毛髪再生 / 毛包再生 / 細胞移植 / ビタミンD / 毛乳頭細胞 / Sphere / sphere
Research Abstract

We established a clinically applicable transplantation method using expanded culture dermal papilla cells for hair regeneration therapy in animal model. This method is less invasive, simple and not required to use embryonic or neonatal keratinocyte. Thus, it is appropriate for clinical use. Furthermore, we developed culturing method to promote hair follicle induced potential of expanded dermal papilla cells by 1α, 25-dyhidroxyvitamin D_3-pretreatment.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration2011

    • Author(s)
      Noriyuki Aoi
    • Journal Title

      JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

      Volume: (In printing)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration.2010

    • Author(s)
      Aoi N, Inoue K, Kato H, Suga H, Higashino T, Eto H, Doi K, Araki J, Iida T, Katsuta T, Yoshimura K.
    • Journal Title

      J Tissue Eng Regen Med In press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 培養細胞移植による毛包再生:移植法および培養法の最適化にむけて2010

    • Author(s)
      青井則之
    • Organizer
      第19回日本形成外科学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Optimization of cell construct grafting procedure for hair regeneration therapy2010

    • Author(s)
      青井則之
    • Organizer
      6^<th> WORLD CONGRESS FOR HAIR RESEARCH
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 1.25-dihydroxy vitamin D and All-Trans Retinoic Acid synergistically enhance Expression of wnt10b and alkaliphosphatase in human dermal cells via vitamin D receptor pathway2010

    • Author(s)
      青井則之
    • Organizer
      6^<th> WORLD CONGRESS FOR HAIR RESEARCH
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 毛髪再生のための毛乳頭細胞コンストラクトの移植法の検討2010

    • Author(s)
      青井則之
    • Organizer
      日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 毛髪のアンチエイジング:培養細胞を用いた毛髪再生の試み2009

    • Author(s)
      青井則之
    • Organizer
      形成外科基礎学会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 毛髪再生用細胞移植方法2010

    • Inventor(s)
      吉村浩太郎, 井上啓太, 佐藤隆博
    • Industrial Property Rights Holder
      株式会社バイオマスター
    • Patent Publication Number
      2010-082339
    • Acquisition Date
      2010-04-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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