Role of P75NTR in peripheral nerve regeneration

Research Project

Project/Area Number	21791743
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Plastic surgery
Research Institution	Osaka University
Principal Investigator	HATA Yuki 大阪大学, 医学部附属病院, 医員 (10351058)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	末梢神経再生 / p75NTR / シュワン細胞 / 創傷治癒 / 線維芽細胞
Research Abstract	Double transgenic mice without P75NTR and with GFP expression in S-100 protein was successfully created. We invented the way to visualize myelin sheath regeneration by peripheral nerve transplantation. In addition, we proved that lack of p75 Low Affinity Nerve Growth Factor Receptor(p75NTR) impairs the migration, proliferation and the differentiation to miofibroblasts in fibroblasts of mice.