The functional analysis of the active peptide of dermatopontin in wound healing
| Project/Area Number |
21791747
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Oita University |
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Principal Investigator |
KATO Aiko Oita University, 医学部, 助教 (50404372)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 創傷治癒 / デルマトポンチン |
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| Research Abstract |
Dermatopontin(DP), one of the dermal extracellular matrix protein, promoted cell adhesion of the human keratinocyte cell line. A synthetic peptide of DP, named DP-4, is critical for the cell adhesive activity of DP. We found DP enhanced cell migration and proliferation. These results suggest that DP and DP-4 promote wound healing. Moreover, we found that DP interacted with fibronectin(Fn), promoted Fn fibril formation, and enhanced cell adhesion. DP-4 also promoted Fn fibril formation, and enhanced cell adhesion. Thus DP and its active peptide DP-4 had an accelerating role in wound healing.
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Report
(3 results)
Research Products
(9 results)
