Studying the significance of miRNA in diabetic wound healing using diabetic animal models

Research Project

Project/Area Number	21791748
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Plastic surgery
Research Institution	University of Miyazaki
Principal Investigator	MADHYASTHA Radha University of Miyazaki, 医学部, 助教 (80381078)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	創傷治癒学 / 創傷治癒 / マイクロRNA / 糖尿病
Research Abstract	This project aimed to investigate the role of microRNAs in diabetic related impaired wound healing. Employing diabetic mouse models, we found that several microRNAs were dysregulated during the period of wound healing. The most significant down-regulation was exhibited by miR-21. Cell culture studies revealed that miR-21 was associated with the migration of fibroblasts and keratinocytes.

Report

(3 results)