Studying the significance of miRNA in diabetic wound healing using diabetic animal models
| Project/Area Number |
21791748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | University of Miyazaki |
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Principal Investigator |
MADHYASTHA Radha University of Miyazaki, 医学部, 助教 (80381078)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 創傷治癒学 / 創傷治癒 / マイクロRNA / 糖尿病 |
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| Research Abstract |
This project aimed to investigate the role of microRNAs in diabetic related impaired wound healing. Employing diabetic mouse models, we found that several microRNAs were dysregulated during the period of wound healing. The most significant down-regulation was exhibited by miR-21. Cell culture studies revealed that miR-21 was associated with the migration of fibroblasts and keratinocytes.
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Report
(3 results)
Research Products
(3 results)
