Comparison of cell properties with bone marrow derived mesenchymal romal cells and umbilical cord derived mesenchymal stromal cells

• Project/Area Number: 21791750
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: Kitasato University
• Principal Investigator: BABA Kyoko Kitasato University, 医学部, 助教 (90327411)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 月齊帯由来間葉系細胞 / 骨組織形成 / 自家組織 / 再生医療 / 口唇口蓋裂 / 臍帯由来間葉系細胞 / 間葉系幹細胞 / 臍帯 / 骨形成

Research Abstract

We verified the osteogenic potential of umbilical cord derived mesenchymal stromal cells (UC-MSCs). There was a difference in osteogenic potential of bone marrow derived mesenchymal stromal cells (BM-MSCs) and that of UC-MSCs. I confirmed that a BM-MSCs was superior to UC-MSCs in osteogenic potential.

Research Products

• [Journal Article] Eiju Uchinuma Potential of regenerative medicine of bone tissue using the autologous umbilical cord and umbilical cord blood 20th Congress of the European Association of Cranio-Maxillp-Facial (2010)
  • Author(s): Kyoko Baba, Yasuharu Yamazaki, Kazuya Aoyagi,Akira Takeda
  • Journal Title: Surgery Pages: 359-363
• [Journal Article] Proliferative and differentialpotentials of human bone marrow-derived mescenchymal cells cultured with autologous serum 20th Congress of the European Association of Cranio-Maxillp-Facial (2010)
  • Author(s): Yasuharu Yamazaki, Akira Takeda, Kyoko Baba, Eiju Uchinuma
  • Journal Title: Surger Pages: 377-382
• [Journal Article] Potential of regenerative medicine of bone tissue using the autologous umbilical cord and umbilical cord blood (2010)
  • Author(s): Kyoko Baba, Yasuharu Yamazaki, Kazuya Aoyanagi, Akira Takeda, Eiju Uchinuma
  • Journal Title: 20th Congress of the European Association of Cranio-Maxillp-Facial Surgery Pages: 359-363
• [Journal Article] proliferative and differential potentials of human bone marrow-derived mescenchymal cells cultured with autologous serum (2010)
  • Author(s): Yasuharu Yamazaki, Akira Takeda, Kyoko Baba, Eiju Uchinuma
  • Journal Title: 20th Congress of the European Association of Cranio-Maxillp-Facial Surger Pages: 377-382
• [Presentation] 臍帯血由来fibrinの自家組織scaffoldとしての可能性 (2011)
  • Author(s): 馬場香子、山崎安晴、武田啓、曽根由美子、内沼栄樹
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2011-03-02
• [Presentation] 自己血清培養下におけるヒト骨髄由来間葉系細胞の増殖能と分化能 (2011)
  • Author(s): 山崎安晴、武田啓、馬場香子、曽根由美子、内沼栄樹
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2011-03-02
• [Presentation] Potential of UCB-derived Plasma as the source of regenerative medicine (2010)
  • Author(s): Kyoko Baba, Akira Takeda, Yasuharu Yamazaki, Kazuya Aoyagi, Eiju Uchinuma
  • Organizer: 12th International Congress of Oriental Society of Aesthetic Plastic
  • Place of Presentation: Surgery Tokyo
  • Year and Date: 2010-11-02
• [Presentation] Potential of UCB-derived Plasma as the source of regenerative medicine (2010)
  • Author(s): Kyoko Baba, Akira Takeda, Yasuharu Yamazaki, Kazuya Aoyanagi, Eiju Uchinuma
  • Organizer: 12th International Congress of Oriental Society of Aesthetic Plastic Surgery
  • Place of Presentation: 東京(品川プリンスホテル)
  • Year and Date: 2010-11-02
• [Presentation] 臍帯由来間葉系幹細胞と膀帯血を用いた骨組織の再生 (2010)
  • Author(s): 馬場香子、武田啓、山崎安晴、青柳和也、曽根由美子、内沼栄樹
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-09-17
• [Presentation] 臍帯由来間葉系幹細胞と臍帯血を用いた骨組織の再生 (2010)
  • Author(s): 馬場香子、武田啓、山崎安晴、青柳和也、曽根由美子、内沼栄樹
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 神奈川(パシフィコ横浜)
  • Year and Date: 2010-09-17
• [Presentation] Potential of regenerative medicine of bone tissue using the autologous umbilical cord and umbilical cord blood (2010)
  • Author(s): Kyoko Baba, Yasuharu Yamazaki, Kazuya Aoyagi, Akira Takeda,Eiju Uchinuma
  • Organizer: 20th Congress of the European Association of Cranio-Maxillp-Facial
  • Place of Presentation: Surgery Belgium
  • Year and Date: 2010-09-14
• [Presentation] proliferative and differential potentials of human bone marrow-derived mescenchymal cells cultured with autologous serum (2010)
  • Author(s): Yasuharu Yamazaki, Akira Takeda, Kyoko Baba, Eiju Uchinuma
  • Organizer: 20th Congress of the European Association of Cranio-Maxillp-Facial
  • Place of Presentation: Surgery Belgium
  • Year and Date: 2010-09-14
• [Presentation] Potential of regenerative medicine of bone tissue using the autologous umbilical cord and umbilical cord blood (2010)
  • Author(s): Kyoko Baba, Yasuharu Yamazaki, Kazuya Aoyanagi, Akira Takeda, Eiju Uchiuuma
  • Organizer: 20th Congress of the European Association of Cranio-Maxillp-Facial Surgery
  • Place of Presentation: Bruges (Belgium)
  • Year and Date: 2010-09-14
• [Presentation] proliferative and differential potentials of human bone marrow-derived mescenchymal cells cultured with autologous serum (2010)
  • Author(s): Yasuharu Yamazaki, Akira Takeda, Kyoko Baba, Eiju Uchinuma
  • Organizer: 20th Congress of the European Association of Cranio-Maxillp-Facial Surgery
  • Place of Presentation: Bruges (Belgium)
  • Year and Date: 2010-09-14
• [Presentation] 臍帯血由来fibrinの自家組織scaffoldとしての可能性 (2010)
  • Author(s): 馬場香子、山崎安晴、武田啓、曽根由美子、内沼栄樹
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-01
• [Presentation] 自己血清培養下におけるヒト骨髄由来間葉系細胞の増殖能と分化能 (2010)
  • Author(s): 山崎安晴、武田啓、馬場香子、曽根由美子、内沼栄樹
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-01
• [Presentation] 臍帯由来間葉系細胞の骨形成能検討 (2010)
  • Author(s): 馬場香子
  • Organizer: 日本再生医療学会
  • Place of Presentation: 広島(広島国際会議場)
• [Presentation] 臍帯由来間葉素細胞の骨形成能の検討 (2009)
  • Author(s): 馬場香子
  • Organizer: 北里フオーラム
  • Place of Presentation: 神奈川(ブリーズベイホテル)
  • Year and Date: 2009-11-28
• [Presentation] 臍帯由来間葉系細胞に対する乏血小板血漿を利用したscaifoldの検討 (2009)
  • Author(s): 馬場香子
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 東京(都市センターホテル)
• [Presentation] 臍帯由来間葉系細胞の分離と骨形成能の検討 (2009)
  • Author(s): 馬場香子
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 東京(都市センターホテル)