| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Skin wounds in mammalian fetuses regenerate and do not leave visible scar, but afterwards it is no longer possible. The intensity of inflammatory response seems to be one of the mechanisms underlining this phenomenon. Investigating the profiles of inflammatory cells recruited to fetal wounds revealed that from day 17 of gestation lots of neutrophils started to be recruited to the wounds, which coincided with the ability to regenerate dermal structures and skin appendages. And injecting neutrophils into the skin wounds of early-stage fetuses delayed the healing. Neutrophil elastase seemed to be one of the factors that inhibit early wound healing of mouse skin.
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