• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability

Research Project

Project/Area Number 21791753
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionKeio University

Principal Investigator

SHIMIZU Ruka  Keio University, 医学部, 研究員 (50445392)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords毛包再生 / 非接着培養 / 線維芽細胞
Research Abstract

Interactions between epithelial and dermal cells are essential for hair follicle morphogenesis and maintenance. In experimental trials of hair regeneration, isolated dermal cells have been shown to possess hair-inducing capacity. However, dermal cells lose this potential immediately after cultivation. Sphere-forming multipotent cells derived from the dermis possess hair-inducing capacity. These previous findings raise the possibility that hair-inducing capacity depends on the process of sphere-formation. To address this issue, we compared the in vitro and in vivo characteristics of two-dimensionally cultured or thereafter sphere formation-induced dermal cells from fetal mice and human, and lung cells from adult mice. Sphere-forming cells but not two-dimensionally cultured cells possessed in vivo hair-inducing capacity.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009 Other

All Journal Article (2 results) Presentation (14 results)

  • [Journal Article] Sphere formation restores and confers hair inducing capacity in cultured mesenchymal cells

    • Author(s)
      Shimizu, Ruka; Okabe, Keisuke; Kubota, Yoshiaki; Nakajima, Hideo; Nakamura-Ishizu, Ayako; Kishi, Kazuo
    • Journal Title

      Experimental Dermatology Epub ahead of print

    • Related Report
      2010 Final Research Report
  • [Journal Article] Sphere formation restores and confers hair inducing capacity in cultured mesenchymal cells

    • Author(s)
      Shimizu Ruka
    • Journal Title

      Experimental Dermatology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
  • [Presentation] ミニシンポジウム「非接着性培養法によるマウス皮膚線維芽細胞の毛包誘導能の獲得」2011

    • Author(s)
      清水瑠加
    • Organizer
      第29回日本臨床皮膚外科学会・第16回日本臨床毛髪学会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-02-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 非接着性培養法によるマウス皮膚線維芽細胞の毛包誘導能の獲得2011

    • Author(s)
      清水瑠加
    • Organizer
      第29回日本臨床皮膚外科学会・第16回日本臨床毛髪学会ミニシンポジウム
    • Place of Presentation
      沖縄
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] "Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability : Cell Aggregation is a Key for Hair Regeneration" (poster)2010

    • Author(s)
      Shimizu R, Kishi K, Okabe K, Kubota Y
    • Organizer
      EMBO conference on Molecular & Cellular Basis of Regeneration & Tissue Repair
    • Place of Presentation
      ポルトガル
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability : Cell Aggregation is a Key for Hair Regeneration2010

    • Author(s)
      Shimizu Ruka
    • Organizer
      EMBO conference on Molecular & Cellular Basis of Regeneration & Tissue Repair
    • Place of Presentation
      ポルトガルセシンブラ
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線維芽細胞の細胞凝集塊の形成と細胞の生存との関係2010

    • Author(s)
      清水瑠加、貴志和生、岡部圭介、久保田義顕
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 線維芽細胞の細胞凝集塊形成による未分化遺伝子の発現2010

    • Author(s)
      清水瑠加、貴志和生、岡部圭介、久保田義顕
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 頭部瘢痕に対する我々の治療法2010

    • Author(s)
      清水瑠加、貴志和生、岡部圭介
    • Organizer
      第2回日本創傷外科学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability : Cell Aggregation isa Key for Hair Regeneration2010

    • Author(s)
      Shimizu R, Kishi K, Okabe K, Kubota Y
    • Organizer
      #74 COEX MEETING
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability : Cell Aggregation is a Key for Hair Regeneration2010

    • Author(s)
      Shimizu Ruka
    • Organizer
      #74 COEX MEETING
    • Place of Presentation
      東京(慶應大学医学部)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability : Cell Aggregation is a Key for Hair Regeneration2010

    • Author(s)
      Shimizu R
    • Organizer
      8th National Australian Wound Management Association Conference
    • Place of Presentation
      オーストラリアパース
    • Year and Date
      2010-03-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非接着培養によるマウス皮膚および肺線維芽細胞を用いた毛包誘導2010

    • Author(s)
      清水瑠加
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Skin derived precursorsを用いた毛包誘導2009

    • Author(s)
      清水瑠加
    • Organizer
      第15回日本臨床毛髪学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト背部皮膚線維芽細胞を用いた毛包誘導2009

    • Author(s)
      清水瑠加
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Abilitv : Cell Aggregation is a Key for Hair Regeneration2009

    • Author(s)
      Ninomiya R
    • Organizer
      5^<th> Joint Meeting of The European Tissue Repair Society & The Wound Healing Society
    • Place of Presentation
      フランスリモージュ
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi