Fibroblast Aggregates Grown in Non-adhesive Culture Obtain Hair Inductive Ability
Project/Area Number |
21791753
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Plastic surgery
|
Research Institution | Keio University |
Principal Investigator |
SHIMIZU Ruka Keio University, 医学部, 研究員 (50445392)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 毛包再生 / 非接着培養 / 線維芽細胞 |
Research Abstract |
Interactions between epithelial and dermal cells are essential for hair follicle morphogenesis and maintenance. In experimental trials of hair regeneration, isolated dermal cells have been shown to possess hair-inducing capacity. However, dermal cells lose this potential immediately after cultivation. Sphere-forming multipotent cells derived from the dermis possess hair-inducing capacity. These previous findings raise the possibility that hair-inducing capacity depends on the process of sphere-formation. To address this issue, we compared the in vitro and in vivo characteristics of two-dimensionally cultured or thereafter sphere formation-induced dermal cells from fetal mice and human, and lung cells from adult mice. Sphere-forming cells but not two-dimensionally cultured cells possessed in vivo hair-inducing capacity.
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Report
(3 results)
Research Products
(16 results)