The role of matrix metalloproteinases (MMPs) in the remodeling of keloids : implications for mechanisms of keloid progression

• Project/Area Number: 21791756
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plastic surgery
• Research Institution: Toho University
• Principal Investigator: IMAIZUMI Risa Toho University, 医学部, シニアレジデント (20453847)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: ケロイド / 正常成熟瘢痕 / MMP-2 / TIMP-2 / MT1-MMP / 膠原線維束

Research Abstract

Keloid is characterized by excessive deposition of collagen, resulting from aberrant extracellular matrix (ECM) production and degradation. Previous studies have demonstrated that collagenases such as matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) are involved in producing and degrading ECM in normal wound healing and that fibroblasts have a crucial role in the expression and activity of MMPs and TIMPs during the process of healing. The present study indicates that MMP-2 activity can be promoted in keloid fibroblasts between collagen bundles in cooperation with TIMP-2 and MT1-MMP. This could contribute to remodelling of collagen bundle regions and invasion of fibroblasts into peripheral normal regions through promoted degradation of ECM.

Research Products

• [Journal Article] The mechanisms underlying fibroblast apoptosis regulated by growth factors during wound healing. (2010)
  • Author(s): Akasaka Y, Imaizumi R(8番目), 他12名
  • Journal Title: J Pathol. 221(3) Pages: 285-99
  • Peer Reviewed
• [Journal Article] Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions : implications for mechanisms of keloid progression. (2009)
  • Author(s): Imaizumi R(1番目), Akasaka Y, 他5名
  • Journal Title: Histopathology. 54(6) Pages: 722-30
  • Peer Reviewed
• [Journal Article] Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions : implications for mechanisms of keloid progression. (2009)
  • Author(s): Risa Imaizumi
  • Journal Title: Histopathology 54 Pages: 722-730
  • Peer Reviewed
• [Presentation] The metalloproteinase (MMP)-2 in the remodeling of keloids : implcations for mechanisms of keloid progression. Pan-Pacific Surgical Association (2010)
  • Author(s): Risa Imaizumi
  • Organizer: 29^<th> BiennialCongress.
  • Place of Presentation: Sheraton Waikiki Hotel, Honolulu, Hawaii
  • Year and Date: 2010-01-14
• [Presentation] The role of matrix metalloproteinase (MMP)-2 in the remodeling of keloids : imphcations for mechanisms of keloid progression (2010)
  • Author(s): Risa Imaizumi
  • Organizer: Pan-Pacific Surgical Association 29^<th> Biennial Congress
  • Place of Presentation: Sheraton Waikiki Hotel, Honolulu, Hawaii
  • Year and Date: 2010-01-14