Adiponectin improves survival rate of septic shock in mice model

Research Project

Project/Area Number	21791764
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Tokyo Medical and Dental University
Principal Investigator	HARAGUCHI Go 東京医科歯科大学, 医学部・附属病院, 助教 (40361729)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	集中治療医学 / 敗血症 / 糖尿病 / 低アディポネクチン血症 / 集中治療と血糖 / アディポネクチン
Research Abstract	Adiponectin transgenic mice were improved survival rate with septic shock compared to wild type mice. Furthermore adiponectin anti-sense transgenic mice, low adiponectin mice were worsened survival rate. Adiponectin suppressed inflammatory signaling in cells involving with septic shock progression.

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(4 results)