Establishment of the early diagnostic method of mesenteric ischemia using d-lactate
| Project/Area Number |
21791770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TATSUMI Hiroomi Sapporo Medical University, 医学部, 助教 (70404613)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 集中治療医学 / 腸管壊死 / 腸管虚血 / 乳酸 / 光学異性体 |
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| Research Abstract |
We measured the change in plasma levels of 1-lactic acid and c-lactic acid, using a rat mesenteric and iliac ischemia model. The plasma level of 01-lactic acid, which is specifically produced in mesenteric ischemia, increased from 30 minutes after ischemia only in mesenteric ischemia group. The rise in plasma level of 1-lactic acid, which is produced in general ischemia of the whole body, was continuously observed in the both groups. The possibility that c-lactic acid become a sensitive marker of mesenteric ischemia and necrosis was indicated, and it was thought that a quick diagnostic kit enabled early diagnosis of mesenteric ischemia and necrosis.
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Report
(3 results)
Research Products
(2 results)
