| Project/Area Number |
21791772
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HASHIMOTO Soshi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (60515279)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 急性肺損傷 / 肺線維化 / 肺胞構築 / 細胞骨格制御タンパク |
|---|
| Research Abstract |
We found out that moesin, a member of the ERM family of cytoskeletal linker proteins, was specifically localized in the distal lung epithelium using immunohistochemical analysis. Although we also found that interstitial cells, including interstitial fibroblasts and infiltrating inflammatory cells expressed moesin protein in the lung of mice treated with bleomycin, we failed to figure out the physiological function of moesin protein. On the other hand, in this experimental and clinical study of ALI/ARDS, we found that the activity of NEP, reported to interact with moesin, was significantly decreased in plasma and increased in the alveolar air space.
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