| Project/Area Number |
21791775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
KIDA Maki Wakayama Medical University, 医学部, 助教 (00326381)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | オステオポンチン / TGFβ / 皮膚創傷治癒 / 線維化 / TGFベータ/Smadシグナル / 皮膚 / 創傷治癒 / 上皮-間葉系移行 / TGFベータ / Smadシグナル |
|---|
| Research Abstract |
Lucking OPN suppressed granulation tissue fomation, the expression of macrophage and extracellular matrix. Moreover, the expression of phosphor Smad2 was reduced in vitro. Loss of osteopontin(OPN), TGF beta/Smad signal was controlled during skin wound healing. As a result, it was suggested that the expression of extracellular matrix was controlled in a condition of lucking OPN.
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