Examination of the efficacy of high-dose immunoglobulin in a rat model of sepsis

Research Project

Project/Area Number	21791776
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Keio University
Principal Investigator	YOSHIKAWA Takahisa Keio University, 医学部, 助教 (80445220)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	集中治療学 / 救急治療医学
Research Abstract	Treatment with immunoglobulin significantly improved survival rate at postoperative day 7 (73% in the high-dose group vs. 33% in the control group ; p=0.037). The serum creatinine and blood urea nitrogen levels were significantly lower in the high-dose group than in the other groups. The serum HMGB1 level had increased at 4 hours postoperatively in the control group (10.2±3.3 ng/ml) and low-dose group (10.3±4.0 ng/ml), but it was significantly reduced in the high-dose group (4.2±0.8 ng/ml) compared to the control group (p=0.03). Our results suggest that high-dose immunoglobulin therapy might improve the pulmonary pathology and overall survival rate in sepsis by inhibiting the inflammation.

Report

(3 results)