Detection of the role of High Mobility Group Box-1 on septic lung injury mice after burn injury.

Research Project

Project/Area Number	21791778
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Keio University
Principal Investigator	ABE Shinya Keio University, 医学部, 助教 (20383896)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	HMGB-1 / 敗血症 / サイトカイン / シグナル伝達 / 免疫学 / 侵襲学
Research Abstract	(1)Construction of the method of making septic lung injury mice after burn injury.(2)Construction of the method of get and stock the samples of blood,lung,liver and spleen of the mice.(3)Construction of the method of measure of cytokines and HMGB-1.(4)Ileum is considered the major place of produce cytokines in intestines of septic lung injury mice after burn injury.