The regulation of Fgf23 gene expression by inorganic phosphate

Research Project

Project/Area Number	21791782
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Morphological basic dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TAMAMURA Yoshihiro Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 特任助教 (70431963)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	Fgf23 / 骨細胞 / 無機リン / マウス / 高リン食 / リン代謝
Research Abstract	The expression of Fgf23 was regulated in bone in response to the change of serum concentration of inorganic phosphate. Calvaria was more sensitive than long bone to induce the expression of Fgf23. The expression of Fgf23 might not be regulated by direct effects of serum phosphate but by in concert with systemic factors. Cell types in bone should be elucidated in response to the change of the serum concentration of inorganic phosphate.

Report

(3 results)