Morphological characterization of type B synoviocytes in the temporomandibular joint focusing on expression of the muscle specific proteins

• Project/Area Number: 21791783
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Niigata University
• Principal Investigator: INOUE Kayoko (NOZAWA Kayoko) 新潟大学, 医歯学系, 特任准教授 (90303130)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 顎関節 / 滑膜 / 滑膜表層細胞 / 筋

Research Abstract

Fibroblast-like type B synoviocytes(type B cells) in the temporomandibular joint(TMJ) are heterogeneous in their morphology and immunoreactivity. This study revealed that some of the type B cells expressed desmin, a muscle-specific intermediate filament, in adult rat TMJ. Immunocytochemical characteristics of the desmin-positive type B cell suggested that this cell does not have myogenic or contractile ability. In addition, their immunoreaction patterns and ultrastructures resembled those of a precursor of a capillary pericyte during angiogenesis.

Research Products

• [Journal Article] Alterations in intermediate filaments expression in disc cells from the rat temporomandibular joint following exposure to continuous compressiveforce (2012)
  • Author(s): Jin Magara, Kayoko Nozawa-Inoue, Akiko Suzuki, Yoshiro Kawano, Kazuhiro Ono, Shuichi Nomura, Takeyasu Maeda
  • Journal Title: Journal of Anatomy Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Alterations in intermediate filaments expression in disc cells from the rat temporomandibular joint following exposure to continuous compressive force (2012)
  • Author(s): Jin Magara (Corresponding author : Kayoko Nozawa-Inoue)
  • Journal Title: Journal of Anatomy Volume: (印刷中)
  • Peer Reviewed
• [Presentation] ラット顎関節におけるデスミン陽性B型表層細胞 (2011)
  • Author(s): 野澤-井上佳世子
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 長良川国際会議場,岐阜
  • Year and Date: 2011-10-01
• [Presentation] ラット顎関節への機械的負荷による関節円板におけるデスミンの発現 (2011)
  • Author(s): 真柄仁
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 長良川国際会議場,岐阜
  • Year and Date: 2011-10-01
• [Presentation] ラット顎関節滑膜におけるデスミン陽性B型表層細胞 (2011)
  • Author(s): 野澤-井上佳世子
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2011-10-01
• [Presentation] ラット顎関節への機械的負荷による関節円板におけるデスミンの発現 (2011)
  • Author(s): 真柄仁
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2011-10-01
• [Presentation] ラット顎関節におけるデスミン陽性B型滑膜表層細胞の免疫細胞化学的特徴 (2011)
  • Author(s): 野澤-井上佳世子
  • Organizer: 第116回日本解剖学会全国学術集会
  • Place of Presentation: Journal of Physiological Sciences誌
  • Year and Date: 2011-03-30
• [Presentation] ラット顎関節におけるデスミン陽性B型滑膜表層細胞の免疫細胞化学的特徴 (2011)
  • Author(s): 野澤-井上佳世子
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: (Journal of Physiological Sciences誌による誌上開催 東北地方太平洋沖地震前の予定)
  • Year and Date: 2011-03-30
• [Presentation] Phenotypic desmin-positive type B synoviocytes in the rat temporomandibular joint (2010)
  • Author(s): Kayoko Nozawa-Inoue
  • Organizer: 88th General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: Barcelona Convention Center, Barcelona, Spain
  • Year and Date: 2010-07-15
• [Presentation] Phenotypic desmin-positive type B synoviocytes in the rat temporomandibular joint (2010)
  • Author(s): Kayoko Nozawa-Inoue
  • Organizer: 88th General Session and Exhibition of the International Association for Dental Research
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-15