Research Project
Grant-in-Aid for Young Scientists (B)
Streptococcus pyogenes (group A streptococci; GAS) is a human pathogen responsible for a wide variety of diseases that ranges from self-limiting purulent infections such as pharyngitis, tonsillitis, and impetigo to severe necrotizing fasciitis and autoimmune diseases including acute rheumatic fever and glomerulonephritis. To successfully evade host immune responses and cause such diverse diseases, GAS might acclimate to environmental changes and control the expression of a variety of genes including virulence genes. In this study, deletion mutants of genes encoding both histidine kinases and response regulators were constructed in a background of a serotype M3 GAS strain. Utilizing these mutant strains and a silkworm infection model, we revealed that several two-component systems are crucial for GAS pathogenesis. Moreover, analysis of the virulence gene expression in mutant strains under several culture conditions indicated specific environmental signals are sensed by two-component systems.
All 2011 2010 2009 Other
All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (20 results) Book (1 results) Remarks (2 results)
Microb Pathog 50(3-4)
Pages: 148-154
J Biol Chem 286(4)
Pages: 2750-2761
Journal of Biological Chemistry
Volume: 286 Pages: 2750-2761
Microbial Pathogenesis
Volume: 50 Pages: 148-154
Biochem Biophys Res Commun 391(2)
Pages: 1192-1196
Infect Immun 77(1)
Pages: 32-44
BMC Genomics 10
Pages: 198-198
Biochemical and Biophysical Research Communications 391
Infection and Immunity 77
Pages: 32-34
http://www.dent.osaka-u.ac.jp/~mcrbio