| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
To clarify the regulation of mechanism of bone metabolism and hematopoietic stem cell niche by estrogen, we used the medullary bone formation model of estrogen-treated male Japanese quails. Medullary bone remodeling was under the control of OPG/RANKL/RANK system. During medullary bone formation period, the population of bone marrow cells shifts from undifferentiated cells to osteoclast precursor cells and osteoblasts on the medullary bone act as a niche cells. These results suggest that estrogen may be related to regulate of hematopoietic stem cell niche.
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