| Project/Area Number |
21791788
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
MINAMIZAKI Tomoko Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (30452593)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞・組織 / 骨代謝 / リン代謝 / カルシウム代謝 / Klotho / FGF23 / 石灰化 / 骨芽細胞 / 再生医学 |
|---|
| Research Abstract |
Klotho forms a complex with FGF23-FGF receptor (FGFR), which is necessary for FGF23-mediated mineralization defects, whereas Klotho is not expressed in bone. We therefore tested the hypothesis that the extracellular domain of Klotho (KLe), which is truncated and secreted into the circulation, contributes to FGF23 action in bone using rat calvaria-derived osteoblasts/osteocytes in vitro and Klotho-mutant mice in vivo. In conclusion, we demonstrated that KLe forms a complex with FGF23-FGFR in bone, resulting in hypomineralization through an FGF23-dependent ERK signaling pathway.
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