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Therapeutic analysis of xerostomia and type I diabetes using cathepsin inhibitor

Research Project

Project/Area Number 21791790
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

YAMADA Akiko  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (70452646)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自己免疫性疾患 / I型糖尿病 / ドライマウス / カテプシン / siRNA / 細胞障害性CD8陽性T細胞
Research Abstract

Xerostomia is caused by several diseases such as Sjogren' s syndrome and diabetes mellitus. Symptomatic therapy is mainly applied for xerostomia. In this study, it was found that specific inhibition of cathepsin L affords strong protection from
cyclophosphamide-induced insulitis and diabetes of NOD mice via inhibiting cytotoxic activity of CD8^+ T cell. Our results showed inhibition of cathepsin L as a powerful therapeutic strategy for autoimmune diabetes and xerostomia.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (45 results)

All 2011 2010 2009 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (28 results) Remarks (1 results)

  • [Journal Article] Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8^+ T cell activity.2010

    • Author(s)
      Yamada A, Ishimaru N, Arakaki R, Katunuma N, Hayashi Y
    • Journal Title

      PLoS ONE. 5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] プロテオミクスで探るミトコンドリアからのシトクロムc漏出機構2010

    • Author(s)
      山本武範, 山田安希子, 篠原康雄
    • Journal Title

      生物物理 50(review)

      Pages: 124-125

    • NAID

      10026476927

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy.2010

    • Author(s)
      Ishimaru N, Nitta T, Arakaki R, Yamada A, Lipp M, Takahama Y, Hayashi Y.
    • Journal Title

      PLoS ONE. 5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新生児におけるダイオキシンへの曝露と自己免疫病の発生2010

    • Author(s)
      石丸直澄, 小橋真之, 山田安希子, 新垣理恵子, 林良夫
    • Journal Title

      臨床免疫・アレルギー科 53(review)

      Pages: 92-96

    • NAID

      40016992928

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8^+ T cell activity2010

    • Author(s)
      Yamada A, 他
    • Journal Title

      PLos ONE

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロテオミクスで探るミトコンドリアからのシトクロムc漏出機構2010

    • Author(s)
      山本武範, 他
    • Journal Title

      生物物理

      Volume: 50 Pages: 124-125

    • NAID

      10026476927

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新生児におけるダイオキシンへの曝露と自己免疫病の発生2010

    • Author(s)
      石丸直澄, 他
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 92-96

    • Related Report
      2010 Annual Research Report
  • [Journal Article] In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy2010

    • Author(s)
      Ishimaru N
    • Journal Title

      PloS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background.2009

    • Author(s)
      Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y.
    • Journal Title

      Am J Pathol. 174

      Pages: 1715-1724

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions.2009

    • Author(s)
      Yamada A, Yamamoto T, Yoshimura Y, Gouda S, Kawashima S, Yamazaki N, Yamashita K, Kataoka M, Nagata T, Terada H, Pfeiffer DR, Shinohara Y.
    • Journal Title

      Biochim Biophys Acta. 1787

      Pages: 1486-1491

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential permeabilization effects of Ca2+ and valinomycin on the inner and outer mitochondrial membranes as revealed by proteomics analysis of proteins released from mitochondria.2009

    • Author(s)
      Yamada A, Yamamoto T, Yamazaki N, Yamashita K, Kataoka M, Nagata T, Terada H, Shinohara Y.
    • Journal Title

      Mol Cell Proteomics. 8

      Pages: 1265-1277

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance.2009

    • Author(s)
      Ishimaru N, Takagi A, Kohashi M, Yamada A, Arakaki R, Kanno J, Hayashi Y.
    • Journal Title

      J Immunol. 182

      Pages: 6576-6586

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of plasmacytoid dendric cells for aberrant class expression in exocrine glands from estrogen-deficient mice of healthy background2009

    • Author(s)
      Arakaki R
    • Journal Title

      American Journal of Pathology 174

      Pages: 1715-1724

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal exposure to loe-dose 2.3.7.8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerancel2009

    • Author(s)
      Ishimaru N
    • Journal Title

      The Journal of Immunology 182

      Pages: 6576-6586

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential permeabilization effects of Ca^<2+> and valinomycin on the inner and outer mitochondrial membranes as revealed by proteomics analysis of proteins released from mitochondria2009

    • Author(s)
      Yamada A
    • Journal Title

      Mol Cell Proteomics 8

      Pages: 1265-1277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions2009

    • Author(s)
      Yamada A
    • Journal Title

      Biochim Biophys Acta 1787

      Pages: 1486-1491

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンLの特異的阻害を介した治療戦略2011

    • Author(s)
      山田安希子
    • Organizer
      第9回口腔医科学フロンティア
    • Place of Presentation
      九州大学歯学部本館1階(福岡市)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Critical Signaling Pathway via CCR7 of Foxp3+CD25+CD4+ Regulatory T Cells for the Egress from Lymph Nodes2010

    • Author(s)
      石丸直澄
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Rapid T cell death viainteraction with CD11b+ macrophages inFas-deficient host2010

    • Author(s)
      大浦律子
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Rapid T cell death via interaction with CD11b+ macrophages in Fas-deficient host2010

    • Author(s)
      大浦律子
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ca^<2+>によって酵母ミトコンドリアに誘起される透過性遷移の解析2010

    • Author(s)
      山本武範
    • Organizer
      第2回日本生物物理学会 中四国支部大会
    • Place of Presentation
      松山大学薬学部(松山市)
    • Year and Date
      2010-05-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ca^<2+>によって酵母ミトコンドリアに誘起される透過性遷移の解析2010

    • Author(s)
      山本武範
    • Organizer
      第2回日本生物物理学会中国四国支部大会
    • Place of Presentation
      愛媛
    • Year and Date
      2010-05-08
    • Related Report
      2010 Final Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンL特異的阻害剤を用いた治療効果の検討2010

    • Author(s)
      山田安希子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] シェーグレン症候群における調節性T細胞の役割2010

    • Author(s)
      石丸直澄
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス関節炎モデル樹状細胞のRANKL/FASシグナルを介した免疫抑制効果2010

    • Author(s)
      松本一真
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] エストロゲン欠乏依存的に唾液腺に誘導される膵ラ氏島アミロイドポリペプチドの機能とその意義2010

    • Author(s)
      新垣理恵子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] I型糖尿病モデルマウスにおけるカテプシンL特異的阻害剤を用いた治療効果の検討2010

    • Author(s)
      山田安希子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] シェーグレン症候群における調節性T細胞の役割2010

    • Author(s)
      石丸直澄
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] エストロゲン欠乏依存的に唾液腺に誘導される膵ラ氏島アミロイドポリペプチドの機能とその意義2010

    • Author(s)
      新垣理恵子
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス関節炎モデル樹状細胞のRANKL/FASシグナルを介した免疫抑制効果2010

    • Author(s)
      松本一真
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Therapeutic analysis by selective inhibition of cathepsin L for autoimmune diabetes in NOD mice2009

    • Author(s)
      Yamada A
    • Organizer
      2009日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場 (大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)causes autoimmunity due to the disruption of T cell tolerance2009

    • Author(s)
      Kohashi M
    • Organizer
      2009日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immune regulation by macrophages through cross-talk between Fas and NF-κB signaling2009

    • Author(s)
      Oura R
    • Organizer
      2009日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] In situ patrolling of regulatory T cells is essential for protecting organ-specific autoimmunity2009

    • Author(s)
      Ishimaru N
    • Organizer
      2009日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] I型糖尿病マウスにおけるカテプシンLを介した治療学的解析2009

    • Author(s)
      山田安希子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] エストロゲン欠乏によって唾液腺に誘導される樹状細胞の同定とその機能2009

    • Author(s)
      新垣理恵子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Local toleranceの破綻による臓器特異的自己免疫疾患の発症機序2009

    • Author(s)
      石丸直澄
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Therapeutic Analysis by Selective Inhibition of Cathepsin L for Autoimmune Diabetes in NOD Mice2009

    • Author(s)
      Yamada A
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Immune Regulation by Macrophages through cross-talk between Fas and NF-B Signaling2009

    • Author(s)
      Oura R
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] In situ patrolling of regulatory T cells is essential for protecting organ-specific autoimmunity2009

    • Author(s)
      Ishimaru N
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Neonatal exposure to low-dose 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCD D) causes autoimmunity due to the disruption of Tcell tolerance2009

    • Author(s)
      Kohashi M
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] I型糖尿病マウスにおけるカテプシンLを介した治療学的解析2009

    • Author(s)
      山田安希子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Local Toleranceの破綻による臓器特異的自己免疫疾患の発症機序2009

    • Author(s)
      石丸直澄
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] エストロゲン欠乏によって唾液腺に誘導される樹状細胞の同定とその機能2009

    • Author(s)
      新垣理恵子
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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