| Project/Area Number |
21791790
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
YAMADA Akiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (70452646)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 自己免疫性疾患 / I型糖尿病 / ドライマウス / カテプシン / siRNA / 細胞障害性CD8陽性T細胞 |
|---|
| Research Abstract |
Xerostomia is caused by several diseases such as Sjogren' s syndrome and diabetes mellitus. Symptomatic therapy is mainly applied for xerostomia. In this study, it was found that specific inhibition of cathepsin L affords strong protection from
cyclophosphamide-induced insulitis and diabetes of NOD mice via inhibiting cytotoxic activity of CD8^+ T cell. Our results showed inhibition of cathepsin L as a powerful therapeutic strategy for autoimmune diabetes and xerostomia.
|
