Therapeutic analysis of xerostomia and type I diabetes using cathepsin inhibitor
| Project/Area Number |
21791790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMADA Akiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (70452646)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自己免疫性疾患 / I型糖尿病 / ドライマウス / カテプシン / siRNA / 細胞障害性CD8陽性T細胞 |
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| Research Abstract |
Xerostomia is caused by several diseases such as Sjogren' s syndrome and diabetes mellitus. Symptomatic therapy is mainly applied for xerostomia. In this study, it was found that specific inhibition of cathepsin L affords strong protection from
cyclophosphamide-induced insulitis and diabetes of NOD mice via inhibiting cytotoxic activity of CD8^+ T cell. Our results showed inhibition of cathepsin L as a powerful therapeutic strategy for autoimmune diabetes and xerostomia.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Ca^<2+>-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions.2009
Author(s)
Yamada A, Yamamoto T, Yoshimura Y, Gouda S, Kawashima S, Yamazaki N, Yamashita K, Kataoka M, Nagata T, Terada H, Pfeiffer DR, Shinohara Y.
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Journal Title
Biochim Biophys Acta. 1787
Pages: 1486-1491
Related Report
Peer Reviewed
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