| Project/Area Number |
21791792
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
王 冰 Kyushu University, 歯学研究院, 学術研究員 (20452716)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | TRPV4 / ラット / 口腔粘膜上皮 / 電気生理 / カルシウム / 低浸透圧 / 口腔感覚 / 口腔上皮 / マウス / 浸透圧刺激 / 膜電流 |
|---|
| Research Abstract |
I hypothesized that oral epithelial cells have perception of multi-stimuli in the oral environment. So I investigated the expression of TRPV4 channels, which were known as sensors for warm temperature, mechanical and chemical stimuli, in rat. T identified TRPV4 expression at mRNA and protein level. To investigate it's functional characters, I took advantage of electrophysiological and Ca2+imaging methods. Using TRPV4 activators and inhibitors, I observed TRPV4 induced currents and Ca2+ mobility.
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