Reception, transduction, and modulation of sweet taste in taste receptor cells : Analysis by using transgenic mice.
Project/Area Number |
21791808
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
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Research Institution | Kyushu University |
Principal Investigator |
YOSHIDA Ryusuke Kyushu University, 大学院・歯学研究院, 助教 (60380705)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 味覚 / 味細胞 / 甘味 / 遺伝子改変マウス / 受容体 / 情報伝達機構 / カンナビノイド / 甘味受容体 / 情報伝逹機構 / レプチン |
Research Abstract |
This study has revealed (1) Endocannabinoids selectively enhance sweet taste via CB1 receptor on sweet sensitive taste cells, (2) Taste cells expressing T1R3, a sweet and umami taste receptor component, that are identified by using T1R3-GFP mice respond to various sweet and/or umami taste stimuli, (3) T1R3-GFP taste cells lacking T1R3, gustducin, or TRPM5 do not respond to taste stimuli, (4) T1R3-GFP taste cells express Gα11, 14, s, q, and i2 as Gα subunits other than gustducin.
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Report
(3 results)
Research Products
(54 results)
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
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Journal Title
Proc.Natl.Acad.Sci.U S A 107
Pages: 935-939
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
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Journal Title
Proc.Natl.Acad.Sci. U S A 107
Pages: 935-939
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Peer Reviewed
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[Journal Article] Discrimination of taste qualities among mouse fungiform taste bud cells.2009
Author(s)
Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y
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Journal Title
J.Physiol. 587
Pages: 4425-4439
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[Journal Article] Discrimination of taste qualities among mouse fungiform taste bud cells2009
Author(s)
Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y
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Journal Title
J.Physiol. 587
Pages: 4425-4439
Related Report
Peer Reviewed
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[Presentation] Endocannabinoids as modulators of sweet taste sensitivities in mice2010
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
Organizer
International Symposium on "Oral Health Science" in 2010
Place of Presentation
福岡
Year and Date
2010-02-06
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[Presentation] Endocannabinoids as modulators of sweet taste sensitivities in mice.2010
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
Organizer
International Symposium on "Oral Health Science"
Place of Presentation
Fukuoka
Related Report
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[Presentation] Taste responses of mouse fungiform taste bud cells expressing gustducin or GAD672009
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
Organizer
The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Place of Presentation
福岡
Year and Date
2009-11-04
Related Report
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[Presentation] Different response properties between Type II and Type III taste bud cells in mouse fungiform papillae2009
Author(s)
Yoshida R, Yasuo T, Murata Y, Jyotaki M, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y
Organizer
ACHEMS 2009, 31^<st> annual meeting
Place of Presentation
Sarasota, FL, USA
Year and Date
2009-04-24
Related Report
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[Presentation] Taste responses of mouse fungiform taste bud cells expressing gustducin or GAD67.2009
Author(s)
Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y
Organizer
The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
Place of Presentation
Fukuoka
Related Report
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[Presentation] Different response properties between Type II and Type III taste bud cells in mouse fungiform papillae.2009
Author(s)
Yoshida R, Yasuo T, Murata Y, Jyotaki M, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y
Organizer
AChemS
Place of Presentation
Sarasota, FL, USA
Related Report
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