To clarify the role of osteoclast fusion in bone homeostasis

• Project/Area Number: 21791813
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Keio University
• Principal Investigator: IWASAKI Ryoutarou Keio University, 医学部, 助教 (30365390)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 歯学 / 発生・分化 / 遺伝子

Research Abstract

We generated a DC-STAMP transgenic mice and analysed it. We find out a Inhibition of DC-STAMP provides both decreased osteoclast activity and increased bone formation by osteoblasts, thereby increasing bone mass in an un-coupled and a tissue specific manner.

Research Products

• [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. (2010)
  • Author(s): Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
  • Journal Title: J Exp Med. 207(4) Pages: 751-762
  • Peer Reviewed
• [Journal Article] The Blimpl-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. (2010)
  • Author(s): Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
  • Journal Title: The Journal of Experimental Medicine Volume: 204 Pages: 751-762
  • Peer Reviewed
• [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. (2009)
  • Author(s): Miyamoto K, Ninomiya K, Sonoda KH, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egashira K, Suda T, Toyama Y, Miyamoto T.
  • Journal Title: Biochem Biophys Res Commun. 383(3) Pages: 373-377
  • Peer Reviewed
• [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. (2009)
  • Author(s): Miyamoto K, Ninomiya K, Sonoda KH, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egashira K, Suda T, Toyama Y, Miyamoto T.
  • Journal Title: Biochem Biophys Res Commun. 383 Pages: 373-377
  • Peer Reviewed
• [Presentation] 破骨細胞の細胞融合は骨量と骨芽細胞の活性を制御する (2010)
  • Author(s): 岩崎良太郎、宮本健史、小山慶介、深谷千絵、中川種昭
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-11
• [Presentation] DC-STAMP regulates bone homeostasis through cell-cell fusion of osteoclasts (2009)
  • Author(s): R.Iwasaki, H.Kawana, S.Asoda, Y.Toyam T.Nakagawa, T.Suda, T.Miyamoto
  • Organizer: The 26th Naito Bonference on osteobiology
  • Place of Presentation: 兵庫県淡路島
  • Year and Date: 2009-11-06
• [Presentation] DC-STAMP regulates bone homeostasis through cell-cell fusion of osteoclasts (2009)
  • Author(s): R.Iwasaki, H.Kawana, S,Asoda, Y.Toyam T.Nakagawa, T.Suda, T.Miyamoto
  • Organizer: The 26^<th> Naito Bonference on osteobiology
  • Place of Presentation: 兵庫県淡路島
  • Year and Date: 2009-11-06
• [Presentation] 破骨細胞の細胞融合は骨量と骨芽細胞の活性を制御する (2009)
  • Author(s): 岩崎良太郎、宮本健史、吉田重之、莇生田整治、中川種昭、河奈裕正
  • Organizer: 第54回口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10
• [Presentation] 破骨細胞の細胞融合は骨量と骨芽細胞の活性を制御する (2009)
  • Author(s): 岩崎良太郎, 宮本健史, 吉田重之, 莇生田整治, 中川種昭, 河奈裕正
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10