Cortical circuit of memory process enhanced by masticatory stimulation

• Project/Area Number: 21791815
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: ONO Yumie Kanagawa Dental College, 歯学部, 准教授 (10360207)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 口腔生理学 / 咀嚼 / 記憶 / 海馬 / 脳磁図 / fMRI / 拡散スペクトラムイメージング / 脳・神経 / 歯学 / 生理学 / MEG / DSI

Research Abstract

We used multimodal brain imaging techniques to investigate how masticatory stimulation (chewing) increases cognitive function during working memory process. High time-resolution recordings of cortical activity by Magnetoencephalography revealed that memory acquisition activates the prefrontal cortex concurrently with the supplemental motor area and the supramarginal gyrus.
Moreover, gum chewing further increases the memory acquisition-related activity in the prefrontal cortex. These results suggest chewing as an easy and useful tool to activate the prefrontal cortex to maintain cognitive function.

Research Products

• [Journal Article] Chewing-induced regional brain activity in edentulous patients who received mandibular implant-supported overdentures : a preliminary report (2011)
  • Author(s): K Kimoto, Y Ono, A Tachibana, Y Hirano, T Otsuka, A Ohno, T Obata, M Onozuka
  • Journal Title: Journal of Prosthodontic Research 55(2) Pages: 89-97
  • NAID: 130004546608
  • Peer Reviewed
• [Journal Article] Occlusion and brain function : mastication as a prevention of cognitive dysfunction (2010)
  • Author(s): Y Ono, T Yamamoto, K Kubo, M Onozuka
  • Journal Title: Journal of Oral Rehabilitation 37(8) Pages: 624-640
  • Peer Reviewed
• [Journal Article] Does chewing facilitate human cognitive function (2010)
  • Author(s): Y Ono
  • Journal Title: Bulletin of Kanagawa Dental College 38(1) Pages: 33-34
  • Peer Reviewed
• [Journal Article] Occlusal disharmony and cognitive function (2010)
  • Author(s): K Kubo, Y Ono, T Yamamoto, I Nagatsu, N Karasawa, M Onozuka
  • Journal Title: Biogenic Amines 23(3) Pages: 115-133
  • Peer Reviewed
• [Journal Article] Occlusal disharmony reduces catecholaminergic system (2010)
  • Author(s): K Kubo, H Miyake, S Fujiwara, T Takeuchi, Y Hasegawa, S Toyota, I Nagatsu, Y Ono, T Yamamoto, M Onozuka, N Karasawa
  • Journal Title: Biogenic Amines 23(1) Pages: 9-18
  • Peer Reviewed
• [Journal Article] Occlusion and brain function: mastication as a prevention of cognitive dysfunction (2010)
  • Author(s): Y.Ono
  • Journal Title: Journal of Oral Rehabilitation Volume: 37 Pages: 624-640
  • Peer Reviewed
• [Journal Article] Does chewing facilitate human cognitive function? (2010)
  • Author(s): Y.Ono
  • Journal Title: Bulletin of Kanagawa Dental College Volume: 38 Pages: 33-34
  • Peer Reviewed
• [Journal Article] Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region (2010)
  • Author(s): K.Kato
  • Journal Title: International Journal of Stomatology & Occlusion Medicine Volume: 3 Pages: 71-75
  • Peer Reviewed
• [Journal Article] 映像による視覚機能への影響と脳活動-3D映像の脳神経活動への影響の検討- (2010)
  • Author(s): 原直人
  • Journal Title: 神経眼科 Volume: 27 Pages: 381-388
  • Peer Reviewed
• [Journal Article] 食前ガムチューイングによる肥満抑制 (2010)
  • Author(s): 包隆穂
  • Journal Title: 神奈川歯学 Volume: 45 Pages: 90-99
  • Peer Reviewed
• [Journal Article] Gum chewing maintains working memory acquisition (2009)
  • Author(s): Y Ono, K Dowaki, A Ishiyama, M Onozuka
  • Journal Title: International Journal of Bioelectromagnetism 11(3) Pages: 130-134
  • Peer Reviewed
• [Journal Article] Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor (2009)
  • Author(s): Y Ono, T Kataoka, S Miyake, K Sasaguri, S Sato, M Onozuka
  • Journal Title: Neuroscience Research 64(4) Pages: 385-390
  • Peer Reviewed
• [Journal Article] Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of histamine H1 receptor (2009)
  • Author(s): Y.Ono
  • Journal Title: Neuroscience Research 64(4) Pages: 385-390
  • Peer Reviewed
• [Journal Article] Chewing rescues stress-attenuated hippocampal synaptic plasticity (2009)
  • Author(s): Y.Ono
  • Journal Title: Bulletin of Kanagawa Dental College 37(1) Pages: 55-59
  • Peer Reviewed
• [Journal Article] Gum chewing maintains working memory acquisition (2009)
  • Author(s): Y.Ono
  • Journal Title: International Journal of Bioelectromagnetism 11(3) Pages: 130-134
  • Peer Reviewed
• [Journal Article] Perceptual switching evokes frontal delta wave activity (2009)
  • Author(s): M.Okada
  • Journal Title: International Journal of Bioelectromagnetism 11(3) Pages: 120-122
  • Peer Reviewed
• [Journal Article] Reconstruction of time correlations among multiple oscillatory neural activities by Beamformer analysis on MEG (2009)
  • Author(s): Y.Iijima
  • Journal Title: International Journal of Bioelectromagnetism 11(4) Pages: 150-154
  • Peer Reviewed
• [Journal Article] Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMPR mice (2009)
  • Author(s): K.Kubo
  • Journal Title: Neuroscience Letters 466 Pages: 109-113
  • Peer Reviewed
• [Presentation] 咀嚼感覚の減少が加齢と共に認知機能の低下を促進する (2011)
  • Author(s): 川畑政綱, 小野弓絵, 大野晃教, 川本翔一, 木本克彦, 小野塚實
  • Organizer: 第88回日本生理学会大会(震災のためJournal of Physiological Sciences論文誌上発表)
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] 認知記憶課題遂行に伴う前頭前野活動の咀嚼刺激による促進 (2011)
  • Author(s): 川本翔一, 川畑政綱, 木本克彦, 小野塚實, 小野弓絵
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-18
• [Presentation] Chewing-induced brain activity in edentulous patients with mandibular implant-supported overdentures (2011)
  • Author(s): K.Kimoto
  • Organizer: 89th General Session & Exhibition of the IADR
  • Place of Presentation: San Diego Convention Center(米国)
  • Year and Date: 2011-03-18
• [Presentation] 認知記憶課題遂行に伴う前頭前野活動の咀嚼刺激による促進 (2011)
  • Author(s): 川本翔一
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2011-03-17
• [Presentation] ガムチューイングは短期記憶課題遂行時の前頭前野活動を促進する:光トポグラフィーによる検討 (2011)
  • Author(s): 川本翔一, 川畑政綱, 木本克彦, 小野塚實, 小野弓絵
  • Organizer: 千葉大学医工学シンポジウム～千葉大学における医工連携の出口戦略～
  • Place of Presentation: 千葉
  • Year and Date: 2011-02-18
• [Presentation] FDG-PET imaging of the rat hypothalamus during stress-coping (2010)
  • Author(s): Y Ono, HC Lin, HH Chen, KY Tzen, M Onozuka, CT Yen
  • Organizer: Society for Neuroscience 40th Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-15
• [Presentation] 咀嚼刺激はヒスタミン神経系を活性化させストレス性の海馬記憶低下を早期に回復させる (2010)
  • Author(s): 小野弓絵
  • Organizer: 第14回日本ヒスタミン学会
  • Place of Presentation: 川崎グランドホテル(神奈川)
  • Year and Date: 2010-10-25
• [Presentation] Chewing restores prefrontal activity during consecutive working memory acquisition (2010)
  • Author(s): S Kawamoto, M Kawahata, K Kimoto, M Onozuka, Y Ono
  • Organizer: Decade of the Mind VI
  • Place of Presentation: Fusionopolis, Singapore
  • Year and Date: 2010-10-19
• [Presentation] Chewing restores prefrontal activity during consecutive working memory acquisition (2010)
  • Author(s): S.Kawamoto
  • Organizer: Decade of the Mind VI
  • Place of Presentation: Fusionopolis(シンガポール)
  • Year and Date: 2010-10-19
• [Presentation] チューイングによるドーパミン神経系の活性化はストレス性の不安行動を抑制する (2010)
  • Author(s): 小野弓絵
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(神戸)
  • Year and Date: 2010-09-04
• [Presentation] 若年期における臼歯喪失が認知機能に与える影響 (2010)
  • Author(s): 川畑政綱, 小野弓絵, 大野晃教, 川本翔一, 堀紀雄, 青木宏道, 木本克彦, 小野塚實
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Masticatory organ and memory function. (2010)
  • Author(s): Y Ono
  • Organizer: International conference on Interdisciplinary Medicine and Occlusion
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-07-29
• [Presentation] Masticatory organ and memory function (2010)
  • Author(s): Y.Ono
  • Organizer: International conference on Interdisciplinary Medicine and Occlusion
  • Place of Presentation: Naturhistorisches Museum Wien(オーストリア)(invited lecture)
  • Year and Date: 2010-07-29
• [Presentation] Chewing counteracts stress-induced anxiety-like behavior by activating the dopaminergic system (2010)
  • Author(s): Y Ono, M Fukui, S Koizumi, M Kawahata, M Onozuka
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] Chewing counteracts stress-induced anxiety-like behavior by activating the dopaminergic system (2010)
  • Author(s): Y.Ono
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: CCIB(スペイン)
  • Year and Date: 2010-07-16
• [Presentation] Chewing prevents stress-induced anxiogenic behavior via activation of the dopaminergic system (2010)
  • Author(s): Y.Ono
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: いわて県民情報センター(岩手)
  • Year and Date: 2010-05-19
• [Presentation] ガムチューイングは短期記憶課題遂行時の前頭前野活動を促進する:光トポグラフィーによる検討 (2010)
  • Author(s): 川本翔一
  • Organizer: 千葉大学医工学シンポジウム
  • Place of Presentation: 千葉大学医学部附属病院(千葉)
  • Year and Date: 2010-02-18
• [Presentation] Masticatory organ and brain function (invited lecture) (2009)
  • Author(s): Y.Ono
  • Organizer: Summer school & IAAID symposium 2009
  • Place of Presentation: 東京国際交流館(東京)
  • Year and Date: 2009-09-19
• [Presentation] PUFA supplementation effects on spatial cognitive ability, brain fatty acid composition, and neurogenesis in hippocampus of SAMP (2009)
  • Author(s): H.Sakuma
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-18
• [Presentation] Increase of frontal delta activity related to perceptual switching (2009)
  • Author(s): M.Okada
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-18
• [Presentation] Chewing suppresses stress-induced phosphorylation of mitogen-activated protein kinases in the periaqueductal gray (2009)
  • Author(s): K.Yamada
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Chewing ameliorates stress-suppressed hippocampal CAl-LTP via activation of histamine H1 rpcentor (2009)
  • Author(s): Y.Ono
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Reduction of occurrence of post-stress arrhythmia by chewing (2009)
  • Author(s): S.Koizumi
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of the histaminergic system (2009)
  • Author(s): Y Ono, T Kataoka, S Koizumi, S Sato, M Onozuka
  • Organizer: he 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-29
• [Presentation] Chewing rescues stress-suppressed hippocampal long-term potentiation via activation of the histaminergic system (2009)
  • Author(s): Y.Ono
  • Organizer: The 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2009-07-29
• [Presentation] Chewing reduces stress induced arrhythmia. (2009)
  • Author(s): S.Koizumi
  • Organizer: The 36th Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2009-07-27
• [Book] 噛むチカラでストレスに勝つ (2011)
  • Author(s): 佐藤貞雄, 小野弓絵, 高原円, 久保金弥, 小野塚實
  • Publisher: 健康と良い友だち社
• [Book] 噛むチカラでストレスに勝つ (2011)
  • Author(s): 小野弓絵(共著)
  • Total Pages: 127
  • Publisher: 健康と良い友だち社
• [Book] Biomagnetism : Interdisciplinary Research and Exploration : Proceedings of the 16th International Conference on Biomagnetism (2009)
  • Author(s): K.Dowaki
  • Publisher: Hokkaido University Press
• [Remarks] ホームページ等
  • URL: http://www.kdcnet.ac.jp/college/rcbos/index.html
• [Remarks] 神奈川歯科大学高次脳・口腔科学研究センター
• [Remarks]
  • URL: http://www.kdecet.ac.jp/college/rcbos/index.html
• [Remarks]
  • URL: http://www.imbs-mastication.org/
• [Remarks]
  • URL: http://www.kdcnet.ac.jp/college/rcbos/index.html
• [Remarks]
  • URL: http://www.imbs-mastication.org/