| Project/Area Number |
21791817
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
NAKAMICHI Yuko Matsumoto Dental University, 総合歯科医学研究所, 講師 (20350829)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | IL-34 / M-CSF / 破骨細胞前駆細胞 / 破骨細胞 / 活性型ビタミンD / 活性型ビタミンD_3 / 加齢 |
|---|
| Research Abstract |
M-CSF and RANKL are essential cytokines for differentiation from macrophages into osteoclasts (OCs). IL-34 is a recently discovered ligand for M-CSF receptor (M-CSFR). Here we show that IL-34 is responsible for the distribution of OC precursors in spleen. On the other hand, M-CSF is responsible for the distribution in bone. We found that active vitamin D could induce OCgenesis in M-CSF-deficient op/op mice. Our previous study showed that active vitamin D enhanced in vivo OCgenesis through the upregulation of RANKL in bone. In present study, we unveiled new roles of active vitamin D in OCgenesis. Active vitamin D upregulates IL-34 expressions in splenic blood vessels and bone. That results in facilitating the mobilization of OC precursors from spleen to blood stream and subsequent their settlement to bone.
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