Role of a new cytokine IL-34 in occurrence of osteoclast precursors and their movement to bone.
| Project/Area Number |
21791817
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
NAKAMICHI Yuko Matsumoto Dental University, 総合歯科医学研究所, 講師 (20350829)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | IL-34 / M-CSF / 破骨細胞前駆細胞 / 破骨細胞 / 活性型ビタミンD / 活性型ビタミンD_3 / 加齢 |
|---|
| Research Abstract |
M-CSF and RANKL are essential cytokines for differentiation from macrophages into osteoclasts (OCs). IL-34 is a recently discovered ligand for M-CSF receptor (M-CSFR). Here we show that IL-34 is responsible for the distribution of OC precursors in spleen. On the other hand, M-CSF is responsible for the distribution in bone. We found that active vitamin D could induce OCgenesis in M-CSF-deficient op/op mice. Our previous study showed that active vitamin D enhanced in vivo OCgenesis through the upregulation of RANKL in bone. In present study, we unveiled new roles of active vitamin D in OCgenesis. Active vitamin D upregulates IL-34 expressions in splenic blood vessels and bone. That results in facilitating the mobilization of OC precursors from spleen to blood stream and subsequent their settlement to bone.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Hypergravity suppresses bone resorption in ovariectomized rats.2011
Author(s)
Ikawa T, Kawaguchi A, OkabeT, Ninomiya T, Nakamichi Y, Nakamura M, Uehara S, Nakamura H, Udagawa N, Takahashi N, Nakamura H, Wakitani S.
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Journal Title
Adv Space Res 47
Pages: 1214-1224
Related Report
Peer Reviewed
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[Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.2010
Author(s)
Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT.
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Journal Title
Biochem Pharmacol 80
Pages: 352-361
Related Report
Peer Reviewed
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