| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
The effects of hardness and palatability of food on neuronal activation were studied using rats. A number of Fos-immunoreactive cells and the enhancement of histamine release were found in the central nucleus of amygdala in hard pellets-fed rats, but not in soft pellets-fed rats. When rats acquired a conditioned aversion to soft pellets, Fos expression and histamine release were increased during feeding. In addition, the microinjection of H_1-antagonist to the bilateral central nucleus of amygdala impaired the aversive response to soft pellets. These observations indicate that the amygdalar histaminergic system is involved in the modulation of palatability related to hardness of food.
|
