| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Research Abstract |
To identify the apoptosis-regulating machinery in p53-defective cancer cell would benefit the better strategy for cancer treatment. Present study revealed bim-dependent apoptotic pathway could survey to eliminate p63-downlagurated dangerous cancer cells. The harmful activation of EMT-inducing factor snail was also monitored by the concomitant cellular p63 downregulation, however, snail could provoke another pathway to evade bim-mediated apoptosis, which suggested the acquisition of higher invasiveness requires second round of evasions both from p53-dependent and p53-independent tumor surveillances.
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