Identification of drug-metabolizing enzymes associated with human tongue carcinogenesis using genetic polymorphisms

Research Project

Project/Area Number	21791827
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Kagoshima University
Principal Investigator	HIRANO Masato 鹿児島大学, 大学院・医歯学総合研究科, 助教 (70381184)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	舌癌 / 薬物代謝酵素 / 遺伝子多型
Research Abstract	We have recently reported that a genetic polymorphism of the type II detoxifying enzyme NQO1 may be a major determinant of the susceptibility of rats to oral squamous-cell carcinoma(OSCC) induced by 4-nitroquinoline 1-oxide(4NQO). To test whether this is also the case in human OSCC, polymorphisms of NQO1, CYP1A1 and GSTP1 were examined in a population-based case-control study. In NQO1 and CYP1A1, the homozygous-variant type was much less common among the subjects in the control group than it was among the OSCC cases. Alternatively, GSTP1 have not yet been completely characterised.

Report

(4 results)