Research for developing drug to inhibit malignant melanoma bone metastasis by targeting Wnt5a signaling
| Project/Area Number |
21791830
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KAGIYA Tadayoshi Iwate Medical University, 歯学部, 助教 (30405774)
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| Research Collaborator |
ANDO Yoshinori 岩手医科大学, 歯学部, 助教 (40583662)
FUJIMURA Akira 岩手医科大学, 歯学部, 教授 (80173459)
TAIRA Masayuki 岩手医科大学, 歯学部, 准教授 (60179398)
FUJIWARA Naoki 岩手医科大学, 歯学部, 講師 (20190100)
ISHIZEKI Kiyoto 岩手医科大学, 歯学部, 准教授 (50057775)
HARADA Hidemitsu 岩手医科大学, 歯学部, 教授 (70271210)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 破骨細胞 / microRNA / マイクロアレイ / 癌 / シグナル伝達 / 歯学 / 病理学 / 発現抑制 |
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| Research Abstract |
Many osteoclasts are formed and resorb bone, in malignant melanoma metastasizing. Then we investigated expression profiling of microRNAs during osteoclast differentiation. During osteoclast formation stimulated by RANKL, which induces osteoclast differentiation, 52 mature microRNAs varied more than twofold between untreated cells and RANKL treated cells. We observed the time-dependent down-regulation of the microRNAs miR-223 and miR-342-3p during osteoclastogenesis. By contrast, the levels of miR-210 and miR-378 increased. It suggests that many microRNAs play roles in osteoclast differentiation.
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Report
(3 results)
Research Products
(18 results)
