• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Continual Gram-negative bacterial challenge accelerates stroke onset SHRSP rats

Research Project

Project/Area Number 21791832
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNihon University

Principal Investigator

KAWATO Takayuki  日本大学, 歯学部, 准教授 (50386075)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords脳卒中 / 歯周病 / 慢性感染症 / 酸化ストレス / 食塩 / 高脂肪食 / 血圧 / P.gingivalis
Research Abstract

This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in Stroke-prone spontaneously hypertensive rats(SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides, as compared to uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in lipopolysaccharide-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, TBARS, and 8-OHdG increased in lipopolysaccharide-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from lipopolysaccharides.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2012 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Continual Gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensiverats2012

    • Author(s)
      Kawato T, Tanaka H, Tabuchi M, Ooshima K, Nakai K, Yamashita Y, Maeno M
    • Journal Title

      Clin Exp Hypertens

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Continual Gram-negative bacterial challenge accelerates stroke onset in stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Takayuki Kawato
    • Journal Title

      Clinical and Experimental Hypertension

      Volume: (in press) Issue: 1 Pages: 28-34

    • DOI

      10.3109/10641963.2012.689042

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 慢性炎症が全身に及ぼす影響へのアプローチ~脳卒中モデル動物を用いた実験からの考察~.シンポジウム5口腔の健康を考える2010

    • Author(s)
      川戸貴行
    • Organizer
      第59回日本口腔衛生学会・総会
    • Place of Presentation
      朱鷺メッセ,新潟
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性炎症が全身に及ぼす影響へのアプローチ~脳卒中モデル動物を用いた実験からの考察~2010

    • Author(s)
      川戸貴行
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 継続的なLPS投与が脳卒中易発性高血圧自然発症ラットの脳卒中発症に与える影響について2010

    • Author(s)
      川戸貴行, 山下喜久, 田中秀樹, 田渕正樹, 本橋正史, 前野正夫
    • Organizer
      第59回日本口腔衛生学会・総会
    • Place of Presentation
      朱鷺メッセ,新潟
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 継続的なLPS投与が脳卒中易発症性高血圧自然発症ラットの脳卒中発症に与える影響について2010

    • Author(s)
      川戸貴行, 山下喜久, 田中秀樹, 田渕正樹, 本橋正史, 前野正夫
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      新潟コンベンションセンター
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi