| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. CXCL12 is a chemokine that promotes lymphocyte invasion and migration into tissues. However, the mechanism for this process remains incompletely understood. In this study, we show that CXCL12 significantly enhanced NK cell invasion into type I collagen and increase the production of matrix metalloproteinase- 1 (MMP-1). Confocal immunofluorescence studies show that MMP-1 colocalized on NK cell surface that was stimulated by CXCL12.
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