Tertiary dentin formation induced by GaAlAs laser irradiation in the dental pulp : An immunohistochemical study

• Project/Area Number: 21791845
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Niigata University
• Principal Investigator: SHIGETANI Yoshimi Niigata University, 医歯学系, 助教 (80397132)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: レーザー / 免疫組織化学 / 歯髄

Research Abstract

This study aimed to clarify pulpal responses to GaAlAs laser irradiation. The output energy determines pulpal healing patterns after GaAlAs laser irradiation : the higher energy induces the apoptosis in the affected dental pulp including odontoblasts followed by active cell proliferation in the intense HSP-25-immunoreactive areas surrounding the degenerative tissue, resulting in abundant tertiary dentin formation. Thus, the optimal GaAlAs laser irradiation elicited intentional tertiary dentin formation in the dental pulp.

Research Products

• [Journal Article] 半導体レーザー照射後のラット臼歯における非コラーゲンタンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 大倉直人, 吉羽邦彦, 吉羽永子, 大島勇人, 興地隆史
  • Journal Title: 日歯保存誌 53(5) Pages: 495-501
  • NAID: 110008006920
  • Peer Reviewed
• [Journal Article] 半導体レーザー照射後のラット臼歯における非コラーゲンタンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 他
  • Journal Title: 日歯保存誌 Volume: 53(5) Pages: 495-501
  • NAID: 110008006920
  • Peer Reviewed
• [Presentation] 半導体レーザー照射後のラット臼歯における非コラーゲンタンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 大倉直人, 吉羽邦彦, 細矢明宏, 吉羽永子, 興地隆史
  • Organizer: 日本歯科保存学会2010年秋季学術大会(第133回) 日歯保存誌,プログラムおよび講演抄録集:161頁
  • Place of Presentation: 北海道
  • Year and Date: 2010-10-29
• [Presentation] 半導体レーザー照射後のラット臼歯における硬組織関連タンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 大倉直人, 吉羽邦彦, 吉羽永子, 興地隆史
  • Organizer: 第31回日本歯内療法学会学術大会 日本歯内療法学会学術大会プログラム・講演抄録集:110頁
  • Place of Presentation: 東京
  • Year and Date: 2010-07-25
• [Presentation] Gene Expression of Mineralized Tissue Matrix Proteins in GaAlAs Laser-irradiated Rat Molars. (2010)
  • Author(s): Shigetani Y, Ohkura N, Sasa N, Yoshiba K, Yoshiba N, Okiji T
  • Organizer: The 8th JEA-KAE Joint Scientific Meeting
  • Place of Presentation: Busan, Korea
• [Presentation] Temporal Changes in mRNA expression of mineralized tissue matrix proteins in GaAlAs laser-irradiated rat molars (2010)
  • Author(s): Shigetani Y, Ohkura N, Hosoya A, Yoshiba N, Yoshiba K, Ohshima H, Okiji T
  • Organizer: IFEA 8th Endodontic World Congress.
  • Place of Presentation: Greece
• [Presentation] 半導体レーザー照射後のラット臼歯における硬組織関連タンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 他
  • Organizer: 日本歯内療法学会
  • Place of Presentation: 東京
• [Presentation] TEMPORAL CHANGES IN mRNA EXPRESSION OF MINERALIZED TISSUE MATRIX PROTEINS IN GaAlAs LASER-IRRADIATED RATMOLARS (2010)
  • Author(s): Shigetani Y, et al.
  • Organizer: IFEA 8th Endodontic World Congress
  • Place of Presentation: Greece
• [Presentation] 半導体レーザー照射後のラット臼歯における非コラーゲンタンパクの遺伝子発現 (2010)
  • Author(s): 重谷佳見, 他
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 岐阜
• [Presentation] Gene Expression of Mineralized Tissue Matrix Proteins in GaAlAs Laser-irradiated Rat Molars (2010)
  • Author(s): Shigetani Y, et al.
  • Organizer: JEA-KAE Joint Scientific Meeting
  • Place of Presentation: Busan, Korea
• [Presentation] 半導体レーザー照射後のラット臼歯歯髄反応に関する免疫組織学的検討 (2009)
  • Author(s): 笹なつき, 重谷佳見, 他
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-29
• [Presentation] 半導体レーザー照射に対するラット臼歯歯髄初期反応 (2009)
  • Author(s): 笹なつき, 重谷佳見, 吉羽邦彦, 吉羽永子, 監物新一, 大島勇人, 興地隆史
  • Organizer: 第51回歯科基礎医学会学術大会 Journal of Oral Biosciences 51(Supplement), 100頁
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-10
• [Presentation] 半導体レーザー照射に対するラット臼歯歯髄初期反応 (2009)
  • Author(s): 笹なつき, 重谷佳見, 他
  • Organizer: 歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-10
• [Presentation] Early Pulpal Responses to GaAlAs Laser Irradiation in Rat Molars (2009)
  • Author(s): Shigetani Y, et al.
  • Organizer: APEC, KAE, JEA
  • Place of Presentation: Tokyo
  • Year and Date: 2009-04-25
• [Presentation] 半導体レーザー照射後のラット臼歯歯髄反応に関する免疫組織学的検討 (2009)
  • Author(s): 笹なつき, 重谷佳見, 鈴木啓展, 吉羽邦彦, 吉羽永子, 興地隆史
  • Organizer: 日本歯科保存学会2009年秋季学術大会(第131回) プログラムおよび講演抄録集:188頁
  • Place of Presentation: 仙台
• [Presentation] Early Pulpal Responses to GaAlAs Laser Irradiation in Rat Molars. (2009)
  • Author(s): Shigetani Y, Sasa N, Suzuki H, Yoshiba K, Yoshiba N, Okiji T
  • Organizer: The Asian Pacific Endodontic Confederation (APEC), the Korean Academy of Endodontics (KAE) and Japan Endodontic Association (JEA) are going to co-host the 15th APEC Scientific Congress
  • Place of Presentation: Tokyo
• [Remarks] ホームページ等