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Characterization of stem cells from human exfoliated deciduous teeth (SHED) for mineralized tissue regeneration

Research Project

Project/Area Number 21791848
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionNagoya University

Principal Investigator

NAKAMURA Sayaka  Nagoya University, 医学部附属病院, 医員 (40437033)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生医療 / 歯髄 / 乳歯 / 幹細胞 / 組織工学
Research Abstract

Stem cells from human exfoliated deciduous teeth (SHED) have been identified as a novel population of stem cells. In this study, we focused on the characterization and possibility of mineralized tissue regeneration using SHED. These results suggested that SHED possesses adequate osteogenic/odontogenic capacity and is able to provide enough number of cells for clinical application easily because of high proliferation capacity. SHED that is generally discarded as medical waste and can be obtained without any invasion could be useful cell source for mineralized tissue formation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (24 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration.2011

    • Author(s)
      Katagiri W., Yamada Y., Nakamura S., Ito K., Hara K., Hibi H., Ueda M.
    • Journal Title

      Oral science Int. in press.

    • NAID

      10027680495

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and possibility of novel cell therapy.2011

    • Author(s)
      Nishino, Y
    • Journal Title

      Cytotherapy

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the Wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration.2011

    • Author(s)
      Katagiri, W
    • Journal Title

      Oral science Int

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal perspectives from Asia : Current and future periodontal tissue engineering.2011

    • Author(s)
      Izumi, Y
    • Journal Title

      Periodontol 2000

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow.2010

    • Author(s)
      Yamada Y., Ito K., Nakamura S., Ueda M., Nagasaka T.
    • Journal Title

      Cell Transplant. Nov 5(Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and possibility of novel cell therapy.2010

    • Author(s)
      Nishino Y., Yamada Y., Ebisawa K., Nakamura S., Okabe K., Umemura E., Hara K., Ueda M.
    • Journal Title

      Cytotherapy in press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology.2010

    • Author(s)
      Yamada Y, Nakamura S, Ito K, Sugito T, Yoshimi R, Nagasaka T, Ueda M.
    • Journal Title

      Tissue Eng Part A. (Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow.2010

    • Author(s)
      Yamada, Y
    • Journal Title

      Cell Transplant

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology.2010

    • Author(s)
      Yamada, Y
    • Journal Title

      Tissue Eng Part A. (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem Cell Proliferation Pathways Comparison Between Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells by Gene Expression Profile From Promising Dental Pulp.2009

    • Author(s)
      Nakamura S., Yamada Y., Katagiri W., Sugito T., Ito K., Ueda M.
    • Journal Title

      J Endod. Nov;35(11)

      Pages: 1536-1542

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem Cell Proliferation Pathways Comparison Between Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells by Gene Expression Profile From Promising Dental Pulp2009

    • Author(s)
      Nakamura, S
    • Journal Title

      J Endod 35(11)

      Pages: 1536-1542

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembling peptide nanofiber scaffolds, platelet rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering.2009

    • Author(s)
      Yoshimi, R
    • Journal Title

      J Craniofac Surg 20(5)

      Pages: 1523-1530

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乳歯幹細胞研究バンク2009

    • Author(s)
      中村さやか
    • Journal Title

      総合臨床 58

      Pages: 33-35

    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子プロファイリングによる骨髄幹細胞と歯髄幹細胞のキャラクタライズスタディー2010

    • Author(s)
      原憲史
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell-based therapy with dental pulp stem cells for bone regeneration.2010

    • Author(s)
      Yamada, Y., Nakamura, S., Ito, K., Katagiri, W., Umemura, E., Hara, K., Hibi, H., Ueda, M.
    • Organizer
      International Association for Dental Research (88nd General session of the pan European region of IADR), Barcelona
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Proliferation of SHED and relation to Wnt signaling pathway.2010

    • Author(s)
      Katagiri, W., Yamada, Y., Nakamura, S., Ito, K., Katagiri, W., Umemura, E., Hara, K., Hibi, H., Ueda, M.
    • Organizer
      International Association for Dental Research (88nd General session of the pan European region of IADR)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Cell-based therapy with dental pulp stem cells for bone regeneration.2010

    • Author(s)
      Yamada, Y
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proliferation of SHED and relation to Wnt signaling pathway.2010

    • Author(s)
      Katagiri, W
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optimized study for dental pulp stem cell-based therapy by ready-to-use.2010

    • Author(s)
      Umemura, E., Yamada, Y., Nakamura, S., Ito, K., Katagiri, W., Hara, K., Ueda, M.
    • Organizer
      International Association for Dental Research (88nd General session of the pan European region of IADR)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Optimized study for dental pulp stem cell-based therapy by ready-to-use.2010

    • Author(s)
      Umemura, E
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of dental pulp stem cells for mineralized tissue regeneration.2010

    • Author(s)
      Nakamura, S., Yamada, Y., Katagiri, W., Ito, K., Umemura, E., Ueda, M.
    • Organizer
      International Association for Dental Research (88nd General session of the pan European region of IADR)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of dental pulp stem cells for mineralized tissue regeneration.2010

    • Author(s)
      Nakamura, S
    • Organizer
      International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳歯および永久歯歯髄細胞による骨再生・インプラント治療への応用2010

    • Author(s)
      中村さやか
    • Organizer
      第132回日本歯科保存学会春季学術大会
    • Place of Presentation
      熊本
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳歯および永久歯歯髄細胞による骨再生・インプラント治療への応用2010

    • Author(s)
      中村さやか, 山田陽一, 伊藤憲治, 上田実
    • Organizer
      第132回日本歯科保存学会学術大会
    • Place of Presentation
      熊本
    • Related Report
      2010 Final Research Report
  • [Presentation] 乳歯・永久歯由来歯髄幹細胞による顎顔面領域再生への可能性2009

    • Author(s)
      山田陽一, 伊藤憲治, 中村さやか, 片桐渉, 杉戸孝行, 吉見涼子, 西野雄大, 日比英晴, 上田実
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト乳歯歯髄由来幹細胞の細胞特性の検討:増殖能とWnt/βカテニン経路の関連2009

    • Author(s)
      片桐渉
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳歯歯髄幹細胞による皮膚創傷治癒効果の検討2009

    • Author(s)
      西野雄大
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization and possibility of bone regeneration for dental implant using dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) as novel stem cell origin.2009

    • Author(s)
      Nakamura S., Yamada Y., Katagiri W., Sugito T., Ito K., Ueda M.
    • Organizer
      18th Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Monaco
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical application using injectable tissueengineered bone for minimally invasive and aesthetic dental implant treatment.2009

    • Author(s)
      Yamada Y., Ito K., Nakamura S., Yoshimi R., Hibi H., Baba S., Ueda M.
    • Organizer
      18th Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Monaco
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯髄幹細胞による再生医療を用いたインプラント治療への応用-乳歯、永久歯歯髄幹細胞による骨再生パラダイムシフト-2009

    • Author(s)
      山田陽一, 伊藤憲治, 中村さやか, 片桐渉, 馬場俊輔, 上田実
    • Organizer
      第39回日本口腔インプラント学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 乳歯および永久歯歯髄細胞の遺伝子発現プロファイルの比較検討2009

    • Author(s)
      中村さやか, 山田陽一, 片桐渉, 杉戸孝行, 伊藤憲治, 上田実
    • Organizer
      第130回日本歯科保存学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 歯髄幹細胞による創傷治癒、骨再生医療への展開-乳歯・永久歯歯髄幹細胞の比較-2009

    • Author(s)
      山田陽一, 中村さやか, 片桐渉, 杉戸孝行, 西野雄大, 伊藤憲治, 上田実
    • Organizer
      第130回日本歯科保存学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] 幹細胞を用いた再生医療による新規歯周病治療法のパラダイムシフト-臨床経過から-2009

    • Author(s)
      山田陽一、中村さやか、伊藤憲治、日比英晴、上田実
    • Organizer
      第52回日本歯周病学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization and possibility of bone regeneration for dental implant using dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) as novel stem cell origin2009

    • Author(s)
      Nakamura, S
    • Organizer
      18th Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Monaco
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical application using injectable tissueengineered bone for minimally invasive and aesthetic dental implant treatment2009

    • Author(s)
      Yamada, Y
    • Organizer
      18th Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Monaco
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯髄幹細胞による創傷治癒、骨再生医療への展開-乳歯・永久歯歯髄幹細胞の比較2009

    • Author(s)
      山田陽一
    • Organizer
      第130回日本歯科保存学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯髄幹細胞による再生医療を用いたインプラント治療への応用 -乳歯、永久歯歯髄幹細胞による骨再生パラダイムシフト-2009

    • Author(s)
      山田陽一
    • Organizer
      第39回日本口腔インプラント学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Book] 実験医学(再生医療の最前線2010幹細胞の分化誘導と臨床応用 歯髄幹細胞の再生医療における可能性)(第3章)2010

    • Author(s)
      山田陽一、中村さやか、上田実
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学 再生医療の最前線2010 第3章 幹細胞の分化誘導と臨床応用 歯髄幹細胞の再生医療における可能性2010

    • Author(s)
      山田陽一
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 実験医学再生医療の最前線2010 第3章 幹細胞の分化誘導と臨床応用 歯髄幹細胞の再生医療における可能性2010

    • Author(s)
      山田陽一
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 乳歯歯髄幹細胞に特徴的な遺伝子発現群の利用2009

    • Inventor(s)
      山田陽一、中村さやか、上田実
    • Industrial Property Rights Holder
      名古屋大学
    • Filing Date
      2009-05-20
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 乳歯歯髄幹細胞に特徴的な遺伝子発現群の利用2009

    • Inventor(s)
      山田陽一、中村さやか、上田実
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2009-122379
    • Filing Date
      2009-05-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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